Epoxide Hydrolase Inhibitor
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ARM1
0 ImagesSynonyms: 4BSAARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM.
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sEH inhibitor-7
0 ImagessEH inhibitor-7 is an sEH inhibitor, with an IC50 of 0.15 μM against mouse sEH and an IC50 of 6.2 μM against h-sEH. sEH inhibitor-7 can be used in studies related to hypertension and inflammation.
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1,3-Dibenzylurea
0 ImagesCat. No.: HY-W097200CAS No.: 1466-67-7Synonyms: N,N′-Dibenzylurea1,3-Dibenzylurea is an insect growth regulator and a mouse soluble epoxide hydrolase (MsEH) inhibitor.
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CUDA disodium
0 ImagesCat. No.: HY-121538APurity: 98.0%CUDA disodium is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA disodium selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA disodium may be valuable for the research of cardiovascular disease.
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sEH inhibitor-1
0 ImagessEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
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(Rac)-EC5026
0 ImagesSynonyms: (Rac)-BPN-19186(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB).
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1-Cyclohexyl-3-dodecyl urea
0 ImagesSynonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.
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sEH inhibitor-19
0 ImagesCat. No.: HY-170492CAS No.: 3107483-12-2sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models.
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DJ-53
0 ImagesCat. No.: HY-168144DJ-53 (compund 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor.
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sEH inhibitor-17
0 ImagessEH inhibitor-17 (compound 4f) is an oral active soluble epoxide hydrolase (sEH) inhibitor with the IC50 of 2.94 nM. sEH inhibitor-17 shows anti-inflammatory efficacy.
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sEH inhibitor-6
0 ImagesCat. No.: HY-148000CAS No.: 1205963-04-7sEH inhibitor-6 (Compound 3g) is a soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 0.5 nM.
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sEH inhibitor-16
0 ImagesCat. No.: HY-155029CAS No.: 2999636-75-6sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.
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Thalictoside
0 ImagesCat. No.: HY-N15524CAS No.: 74213-96-0Thalictoside is found in A. squamosa L. Thalictoside is a sEH inhibitor (IC50: 20.2 µM). Thalictoside exerts anti-osteoporotic effects through an estrogen-like mechanism. Thalictoside can be used in the research of cardiovascular and urinary diseases.
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(E)-3-Feruloylquinic acid
0 ImagesCat. No.: HY-W587945CAS No.: 87099-72-7Synonyms: (E)-3-O-Feruloylquinic acid(E)-3-Feruloylquinic acid (Compound 3) is a chlorogenic acid. (E)-3-Feruloylquinic acid can be isolated from the aerial parts of Tetrastigma hemsleyanum. (E)-3-Feruloylquinic acid inhibits soluble epoxide hydrolase (sEH) with an IC50 of 60.7 μM. (E)-3-Feruloylquinic acid can be used in the study of vascular system diseases.
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sEH/FLAP-IN-2
0 ImagesCat. No.: HY-179441sEH/FLAP-IN-2 is a selective sEH (IC50 = 12.6 nM)/FLAP dual inhibitor. sEH/FLAP-IN-2 highlights the reduction of 5-LOX/FLAP- and sEH-derived LMs, resulting in a favourable redistribution of LMs. sEH/FLAP-IN-2 can be used for the study of peritonitis.
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sEH inhibitor-10
0 ImagesCat. No.: HY-151616sEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC50=0.5 μM). sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases.
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Dual FAAH/sEH-IN-1
0 ImagesCat. No.: HY-144738CAS No.: 2756099-59-7Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase.
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COX-2/sEH-IN-1
0 ImagesCat. No.: HY-146704CAS No.: 2474977-38-1COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks.
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Hydroxytyrosol 1-O-glucoside
0 ImagesCat. No.: HY-169750CAS No.: 76873-99-9Synonyms: Dopaol glucosideHydroxytyrosol 1-O-glucoside (Dopaol glucoside) is a glycoside with antioxidant activity. Hydroxytyrosol 1-O-glucoside is also an epoxide hydrolase 2 inhibitor.
