1. Epigenetics
  2. Epigenetic Reader Domain

(+)-JQ1 PA 

Cat. No.: HY-112789 Purity: 98.26%
Handling Instructions

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.

For research use only. We do not sell to patients.

(+)-JQ1 PA Chemical Structure

(+)-JQ1 PA Chemical Structure

CAS No. : 2115701-93-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 710 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.

IC50 & Target

10.4 nM (BET)[1].

In Vitro

(+)-JQ1 PA is a derivative of JQ1, which is the inhibitor of BET. The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2834 mL 11.4168 mL 22.8337 mL
5 mM 0.4567 mL 2.2834 mL 4.5667 mL
10 mM 0.2283 mL 1.1417 mL 2.2834 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Proliferation of MV4;11 cells after 72 hours of treatment, comparing JQ1 versus JQ1-PA are tested. Cell cycle profile of MV4;11 cells after 48 hours of treatment with DMSO, JQ1, JQ1-PA, or JQ1-TCO (all compounds used at 500 nM) are tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

437.95

Formula

C₂₂H₂₀ClN₅OS

CAS No.

2115701-93-2

SMILES

O=C(NCC#C)C[[email protected]]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
(+)-JQ1 PA
Cat. No.:
HY-112789
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(+)-JQ1 PA

Cat. No.: HY-112789