2. Epigenetics
  3. Epigenetic Reader Domain
  4. (+)-JQ1 PA

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

(+)-JQ1 PA Chemical Structure

(+)-JQ1 PA Chemical Structure

CAS No. : 2115701-93-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in Ethanol USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 185 In-stock
25 mg USD 340 In-stock
50 mg USD 490 In-stock
100 mg USD 720 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

(+)-JQ1 PA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (+)-JQ1 PA

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

10.4 nM (BET)[1].
In Vitro

(+)-JQ1 PA is a derivative of JQ1, which is the inhibitor of BET. The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-JQ1 PA Related Antibodies
Molecular Weight

437.95

Formula

C22H20ClN5OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCC#C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (114.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2834 mL 11.4168 mL 22.8337 mL
5 mM 0.4567 mL 2.2834 mL 4.5667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Cell Assay
[1]

Proliferation of MV4;11 cells after 72 hours of treatment, comparing JQ1 versus JQ1-PA are tested. Cell cycle profile of MV4;11 cells after 48 hours of treatment with DMSO, JQ1, JQ1-PA, or JQ1-TCO (all compounds used at 500 nM) are tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.2834 mL 11.4168 mL 22.8337 mL 57.0841 mL
5 mM 0.4567 mL 2.2834 mL 4.5667 mL 11.4168 mL
10 mM 0.2283 mL 1.1417 mL 2.2834 mL 5.7084 mL
15 mM 0.1522 mL 0.7611 mL 1.5222 mL 3.8056 mL
20 mM 0.1142 mL 0.5708 mL 1.1417 mL 2.8542 mL
25 mM 0.0913 mL 0.4567 mL 0.9133 mL 2.2834 mL
30 mM 0.0761 mL 0.3806 mL 0.7611 mL 1.9028 mL
40 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.4271 mL
50 mM 0.0457 mL 0.2283 mL 0.4567 mL 1.1417 mL
60 mM 0.0381 mL 0.1903 mL 0.3806 mL 0.9514 mL
80 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7136 mL
100 mM 0.0228 mL 0.1142 mL 0.2283 mL 0.5708 mL
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(+)-JQ1 PA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-JQ1 PA2115701-93-2Epigenetic Reader DomainInhibitorinhibitorinhibit

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