Selisistat
Based on 313 publication(s) in Google Scholar
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.92%
- CAS. Nr.: 49843-98-3
- Formel: C13H13ClN2O
- Molecular Weight:248.71
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) Selisistat
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Biologische Aktivität
IC50: 123 nM (SirT1)[2]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
29 μM
Compound: EX-527
|
Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HCT-116 | IC50 |
37 μM
Compound: EX-527
|
Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HEK-293T | IC50 |
51 μM
Compound: EX-527
|
Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HeLa | IC50 |
>100 μM
Compound: 1
|
Inhibitory activity against human HDAC in HeLa cell extract by fluorimetric assay
Inhibitory activity against human HDAC in HeLa cell extract by fluorimetric assay
|
[PMID: 16335928] |
| HepG2 | IC50 |
44 μM
Compound: EX-527
|
Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| Hs 683 | IC50 |
115.9 μM
Compound: 3; EX-527
|
Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay
Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay
|
[PMID: 28475330] |
| HT-29 | IC50 |
>100 μM
Compound: EX-527
|
Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HUVEC | IC50 |
15 μM
Compound: EX-527
|
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| K562 | IC50 |
60 μM
Compound: EX-527
|
Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| MCF7 | IC50 |
37 μM
Compound: EX-527
|
Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| NCI-H460 | IC50 |
1 μM
Compound: 59
|
Inhibition of SIRT-2 in human NCI-H460 cells assessed as inhibition of p53 deacetylation after 6 hrs by immunoprecipitation/immunoblotting analysis
Inhibition of SIRT-2 in human NCI-H460 cells assessed as inhibition of p53 deacetylation after 6 hrs by immunoprecipitation/immunoblotting analysis
|
10.1039/C1MD00199J |
| NCI-H460 | IC50 |
48 μM
Compound: EX-527
|
Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| U-373MG ATCC | IC50 |
157.4 μM
Compound: 3; EX-527
|
Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
|
[PMID: 28475330] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 49843-98-3
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Appearance Solid
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Molecular Weight 248.71
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Formel C13H13ClN2O
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Color Off-white to light yellow
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SMILES
O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
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Synonyms
EX-527
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (313)
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Journal Impact Factor
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Most Recent
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Cell Metab
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]2024 Aug 6;36(8):1806-1822.e11. PMID: 38897198 -
Cell Metab
2021 Jan 5;33(1):110-127.e5. PMID: 33171124 -
Nat Immunol
Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity. [Abstract]2022 Aug;23(8):1193-1207. PMID: 35879450 -
Nat Commun
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. [Abstract]2025 Feb 25;16(1):1774. PMID: 40000627 -
J Adv Res
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. [Abstract]2025 Mar 31:S2090-1232(25)00218-8. PMID: 40174640 -
Redox Biol
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer. [Abstract]2025 Oct:86:103834. PMID: 40850192 -
Redox Biol
SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3. [Abstract]2024 Feb:69:103030. PMID: 38181705 -
Mol Cell
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. [Abstract]2020 Jul 16;79(2):304-319.e7. PMID: 32679077 -
Gut Microbes
2025 Dec;17(1):2467193. PMID: 39976263 -
J Nanobiotechnology
Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury. [Abstract]2025 May 8;23(1):339. PMID: 40340852 -
Acta Pharm Sin B
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR. [Abstract]2023 Feb;13(2):559-576. PMID: 36873184 -
J Exp Clin Cancer Res
2024 Sep 30;43(1):275. PMID: 39350280 -
Adv Sci (Weinh)
Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection. [Abstract]2025 Oct 14:e11734. PMID: 41085014 -
Cell Death Dis
S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis. [Abstract]2024 Jun 28;15(6):462. PMID: 38942784 -
Cell Mol Biol Lett
IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin. [Abstract]2024 Feb 2;29(1):22. PMID: 38308199 -
Pharmacol Res
N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation. [Abstract]2022 Nov:185:106491. PMID: 36244543 -
Cell Death Dis
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer. [Abstract]2022 Aug 17;13(8):717. PMID: 35977926 -
Cell Death Dis
IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. [Abstract]2021 May 18;12(6):501. PMID: 34006836 -
J Neuroinflammation
FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation. [Abstract]2025 Nov 26;22(1):280. PMID: 41299504 -
J Neuroinflammation
MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model. [Abstract]2021 Dec 10;18(1):287. PMID: 34893074 -
Phytomedicine
Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways. [Abstract]2026 Jul:156:158188. PMID: 42068872 -
Phytomedicine
Zanthoxylum nitidum-derived active alkaloid nitidine chloride mitigates ulcerative colitis by remodeling gut microbiota and activating SIRT1 to restore intestinal barrier integrity. [Abstract]2026 Jun 15:159:158435. PMID: 42322763 -
Phytomedicine
Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis. [Abstract]2026 Apr:153:157998. PMID: 41775214 -
Phytomedicine
Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1. [Abstract]2026 Apr:153:157997. PMID: 41759420 -
Phytomedicine
Tetramethylpyrazine alleviates ventricular remodeling after myocardial infarction by regulating Sirt1/p300/Yy1/sST2 signaling axis. [Abstract]2026 Jan:150:157662. PMID: 41371162 -
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Phytomedicine
2023 Sep:118:154906. PMID: 37354698 -
Phytomedicine
Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. [Abstract]2022 Sep:104:154271. PMID: 35777120 -
Phytomedicine
Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway. [Abstract]2022 Sep:104:154289. PMID: 35785561 -
Mater Today Bio
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction. [Abstract]2022 Dec 5:18:100512. PMID: 36536658 -
J Hazard Mater
Excessive mitochondrial stress response triggers neuronal injury through the persistent eIF2α phosphorylation in mice exposed to manganese. [Abstract]2025 Sep 15:496:139407. PMID: 40763529 -
Cell Death Discov
2026 Mar 19;12(1):156. PMID: 41856994 -
Cell Death Discov
2025 Dec 6. PMID: 41353172 -
Acta Pharmacol Sin
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway. [Abstract]2024 Feb;45(2):366-377. PMID: 37770579 -
Acta Pharmacol Sin
Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10. [Abstract]2023 Oct;44(10):2125-2138. PMID: 37277492 -
Acta Pharmacol Sin
Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress. [Abstract]2022 Jul;43(7):1721-1732. PMID: 34853445 -
Acta Pharmacol Sin
2022 Feb;43(2):457-469. PMID: 33850273 -
J Cachexia Sarcopenia Muscle
TRIM16 facilitates SIRT-1-dependent regulation of antioxidant response to alleviate age-related sarcopenia. [Abstract]2024 Oct;15(5):2056-2070. PMID: 39192479 -
J Transl Med
β-Nicotinamide mononucleotide activates the SIRT1/NF-κB pathway to alleviate ischemia reperfusion injury after lung transplantation. [Abstract]2025 Nov 25;23(1):1349. PMID: 41291722 -
J Transl Med
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis. [Abstract]2023 Dec 19;21(1):921. PMID: 38115075 -
J Transl Med
An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway. [Abstract]2023 Jul 20;21(1):486. PMID: 37475042 -
J Transl Med
Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis. [Abstract]2020 Feb 17;18(1):84. PMID: 32066482 -
Proc Natl Acad Sci U S A
2019 Feb 19;116(8):2961-2966. PMID: 30718431 -
Dev Cell
2025 Apr 7;60(7):1008-1017.e7. PMID: 39755115 -
Int J Surg
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis. [Abstract]2025 Jul 2. PMID: 40607908 -
Apoptosis
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo. [Abstract]2022 Dec;27(11-12):1031-1048. PMID: 36125665 -
Int J Biol Macromol
Acetylation of GPRC5A at Lys348 facilitates cisplatin resistance and promotes the recurrence and poor prognosis in ovarian cancer. [Abstract]2026 May:362:152113. PMID: 42009151 -
Int J Biol Macromol
Buckwheat protein-derived peptide ameliorates insulin resistance by directing O-linked N-acetylglucosamine transferase to regulate the SIRT1/PGC1α pathway. [Abstract]2025 Apr;304(Pt 2):140925. PMID: 39947565 -
Int J Biol Macromol
Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo. [Abstract]2018 Dec;120(Pt A):683-692. PMID: 30170064 -
Int J Mol Med
CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats. [Abstract]2026 Jul;58(1):197. PMID: 42169654 -
Neural Regen Res
The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice. [Abstract]2024 Sep 1;19(9):2019-2026. PMID: 38227531 -
Neural Regen Res
2024 Mar;19(3):687-696. PMID: 37721302 -
Int J Mol Med
Erythropoietin suppresses hepatic steatosis and obesity by inhibiting endoplasmic reticulum stress and upregulating fibroblast growth factor 21. [Abstract]2019 Aug;44(2):469-478. PMID: 31173165 -
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Antioxidants (Basel)
Pterostilbene, a Resveratrol Derivative, Improves Ovary Function by Upregulating Antioxidant Defenses in the Aging Chickens via Increased SIRT1/Nrf2 Expression. [Abstract]2024 Aug 1;13(8):935. PMID: 39199181 -
Antioxidants (Basel)
Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling. [Abstract]2023 Aug 22;12(9):1657. PMID: 37759959 -
Antioxidants (Basel)
Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy. [Abstract]2022 Nov 25;11(12):2330. PMID: 36552538 -
Antioxidants (Basel)
Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. [Abstract]2022 Apr 19;11(5):799. PMID: 35624663 -
Phytother Res
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway. [Abstract]2025 Dec 2. PMID: 41331137 -
Phytother Res
Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1/FOXO1a/SOD2 signaling in rats. [Abstract]2022 Jun;36(6):2558-2571. PMID: 35570830 -
Free Radic Biol Med
SIRT1 activation restores PINK1-dependent mitophagy to reverse airway barrier dysfunction in Acinetobacter baumannii infection. [Abstract]2026 Mar 25:250:153-167. PMID: 41895413 -
Free Radic Biol Med
2025 Aug 15:240:491-503. PMID: 40819662 -
Free Radic Biol Med
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats. [Abstract]2025 Feb 1:227:472-484. PMID: 39647799 -
J Anim Sci Biotechnol
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway. [Abstract]2024 Sep 5;15(1):119. PMID: 39232832 -
Am J Chin Med
Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling. [Abstract]2020;48(7):1693-1713. PMID: 33202149 -
Aging Cell
SIRT1 Prevents Lens Epithelial Cell Senescence During Age-Related Cataract via Regulating p66Shc. [Abstract]2025 Sep;24(9):e70155. PMID: 40569566 -
Aging Cell
L-Tryptophan Produced by Bifidobacterium pseudocatenulatum NCU-08 Delays Aging in SAMP8 Mice by Activating the Sirt1/P53/P21/Rb Signaling Pathway. [Abstract]2025 Jul 11:e70166. PMID: 40643197 -
Cell Rep
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics. [Abstract]2024 May 24;43(6):114272. PMID: 38795348 -
Cell Rep
De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function. [Abstract]2023 Dec 1;42(12):113518. PMID: 38041812 -
Cell Rep
Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. [Abstract]2023 Apr 17;42(4):112400. PMID: 37071536 -
Cell Rep
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. [Abstract]2020 Aug 4;32(5):107987. PMID: 32755581 -
Cell Prolif
Targeting ROCK1/YAP1 Axis Ameliorates Inflammation-Induced Prostatic Hyperplasia via Stabilising SIRT1-Dependent Mitochondrial Dynamics. [Abstract]2025 Jul 4:e70085. PMID: 40616266 -
Cell Prolif
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence. [Abstract]2021 Mar;54(3):e12991. PMID: 33522656 -
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Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
Chin Med
Chlorogenic acid attenuates pyrrolizidine alkaloid-induced liver injury through modulation of the SIRT1/FXR signaling pathway. [Abstract]2025 Mar 12;20(1):34. PMID: 40069808 -
Chin Med
Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1α/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats. [Abstract]2023 Sep 15;18(1):119. PMID: 37715217 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Environ Pollut
Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression. [Abstract]2021 Jun 1:278:116840. PMID: 33689947 -
Lipids Health Dis
Puerarin ameliorates metabolic dysfunction-associated fatty liver disease by inhibiting ferroptosis and inflammation. [Abstract]2023 Nov 24;22(1):202. PMID: 38001459 -
J Ethnopharmacol
Quercetin enhances skin flap survival via SIRT1-regulated mitophagy promotion and pyroptosis inhibition. [Abstract]2026 Jun 12:364:121525. PMID: 41831738 -
J Ethnopharmacol
Polysaccharide from Campanumoea javanica Bl. accelerate wound healing via moderating TGF-β1/Smad3 pathways and promoting SIRT1-mediated macrophage polarization in rats. [Abstract]2026 Feb 28:357:120851. PMID: 41232631 -
J Ethnopharmacol
Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway. [Abstract]2025 Jan 31:340:119169. PMID: 39617088 -
J Ethnopharmacol
Exploring the effect of Anshen Dingzhi prescription on hippocampal mitochondrial signals in single prolonged stress mouse model. [Abstract]2024 Apr 6:323:117713. PMID: 38181935 -
J Ethnopharmacol
Bushen Wenyang Huayu Decoction inhibits autophagy by regulating the SIRT1-FoXO-1 pathway in endometriosis rats. [Abstract]2023 May 23:308:116277. PMID: 36806342 -
J Ethnopharmacol
Anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating SIRT1 signaling pathway in senescent mice. [Abstract]2022 Oct 5:296:115361. PMID: 35609756 -
Eur J Med Chem
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD. [Abstract]2023 Nov 15:260:115728. PMID: 37625288 -
J Agric Food Chem
Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. [Abstract]2022 Jun 29;70(25):7704-7715. PMID: 35708276 -
J Agric Food Chem
Sesamol Reverses Myofiber-Type Conversion in Obese States via Activating the SIRT1/AMPK Signal Pathway. [Abstract]2022 Feb 23;70(7):2253-2264. PMID: 35166533 -
J Agric Food Chem
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice. [Abstract]2021 Aug 4;69(30):8428-8439. PMID: 34309383 -
Eur J Med Chem
2020 Apr 15:192:112201. PMID: 32163813 -
J Agric Food Chem
Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux. [Abstract]2019 Jun 26;67(25):7157-7166. PMID: 31146527 -
CNS Neurosci Ther
Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the SIRT1/FOXO1/SLC7A11/GPX4 Pathway. [Abstract]2026 Feb;32(2):e70798. PMID: 41718043 -
CNS Neurosci Ther
Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression-Related Behaviors by Urolithin B via the SIRT1-FOXO1 Pathway. [Abstract]2025 Apr;31(4):e70379. PMID: 40237232 -
CNS Neurosci Ther
Melatonin attenuates scopolamine-induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway. [Abstract]2024 Jul;30(7):e14891. PMID: 39056330 -
Ecotoxicol Environ Saf
Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation. [Abstract]2022 Sep 1:242:113879. PMID: 35841654 -
Biochem Pharmacol
Dapagliflozin ameliorates diabetic kidney disease by inhibiting oxidative stress and AIM2-dependent pyroptosis via SIRT1 activation. [Abstract]2026 Jun 25;251(Pt 2):118200. PMID: 42349619 -
Biochem Pharmacol
Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway. [Abstract]2026 Feb:244:117624. PMID: 41360230 -
Biochem Pharmacol
Estradiol alleviated chemotherapy-induced premature ovarian failure by blocking the ferroptosis via activating ESR2/Sirt1/Nrf2 pathway. [Abstract]2025 Oct 29;243(Pt 1):117481. PMID: 41173058 -
Biochem Pharmacol
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase. [Abstract]2025 Jul:237:116932. PMID: 40189160 -
Cell Mol Life Sci
Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells. [Abstract]2024 Nov 9;81(1):448. PMID: 39520538 -
J Chem Inf Model
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. [Abstract]2023 Aug 14;63(15):4780-4790. PMID: 37486605 -
Life Sci
Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. [Abstract]2020 Sep 15:257:118116. PMID: 32702447 -
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Inflammopharmacology
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo. [Abstract]2025 Nov 21. PMID: 41269477 -
Inflammopharmacology
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling. [Abstract]2025 Feb;33(2):865-883. PMID: 39565473 -
Inflammopharmacology
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis. [Abstract]2024 Apr;32(2):1133-1146. PMID: 38150134 -
Food Funct
Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1. [Abstract]2022 Oct 31;13(21):11307-11320. PMID: 36226790 -
Mol Cell Proteomics
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling. [Abstract]2019 Mar;18(3):520-533. PMID: 30617157 -
Drug Des Devel Ther
Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization. [Abstract]2023 Apr 12:17:1125-1138. PMID: 37077409 -
J Clin Transl Hepatol
Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway. [Abstract]2025 Jun 28;13(6):456-468. PMID: 40474887 -
Cells
2022 Nov 18;11(22):3671. PMID: 36429097 -
Nutrients
Resveratrol and Its Derivatives Diminish Lipid Accumulation in Adipocytes In Vitro-Mechanism of Action and Structure-Activity Relationship. [Abstract]2024 Nov 13;16(22):3869. PMID: 39599655 -
Nutrients
11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway. [Abstract]2022 Jun 6;14(11):2358. PMID: 35684158 -
Eur J Pharmacol
Carnosine protects against cerebral ischemia/reperfusion injury through promoting microglial M2 polarization via SIRT1/NF-κB signaling pathway. [Abstract]2025 Nov 15:1007:178191. PMID: 41062011 -
Eur J Pharmacol
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia. [Abstract]2024 Nov 15:983:176824. PMID: 39265882 -
Eur J Pharmacol
Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice. [Abstract]2021 Dec 15:913:174644. PMID: 34801532 -
Eur J Pharmacol
Salidroside attenuates dextran sulfate sodium-induced colitis in mice via SIRT1/FoxOs signaling pathway. [Abstract]2019 Oct 15:861:172591. PMID: 31401159 -
Int Immunopharmacol
GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathway. [Abstract]2026 Jan 15:169:116010. PMID: 41386184 -
Int Immunopharmacol
Coptisine alleviates intestinal barrier dysfunction and inflammation in TNBS-induced colitis rats and LPS-stimulated human intestinal Caco-2 cells. [Abstract]2025 Dec 10:167:115697. PMID: 41130089 -
Int J Mol Sci
Melatonin Alleviates MBP-Induced Oxidative Stress and Apoptosis in TM3 Cells via the SIRT1/PGC-1α Signaling Pathway. [Abstract]2025 Jun 19;26(12):5910. PMID: 40565373 -
Int J Mol Sci
Combining Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Total Ginsenoside Ginseng Root and Its Impact on Antidepressant Effects. [Abstract]2024 Nov 24;25(23):12606. PMID: 39684318 -
Int J Mol Sci
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway. [Abstract]2024 Nov 22;25(23):12543. PMID: 39684254 -
Int Immunopharmacol
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway. [Abstract]2024 Jun 15:134:112257. PMID: 38759366 -
Int J Mol Sci
Melatonin Attenuates Oxidative Stress-Induced Apoptosis of Bovine Ovarian Granulosa Cells by Promoting Mitophagy via SIRT1/FoxO1 Signaling Pathway. [Abstract]2023 Aug 16;24(16):12854. PMID: 37629033 -
Int Immunopharmacol
Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice. [Abstract]2023 Apr:117:109975. PMID: 36948107 -
Int J Mol Sci
Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1/PGC-1α Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative Damage. [Abstract]2023 Mar 14;24(6):5542. PMID: 36982615 -
Int J Mol Sci
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis. [Abstract]2022 Oct 3;23(19):11718. PMID: 36233020 -
Int Immunopharmacol
Anti-inflammatory effects of curcumin in acute lung injury: In vivo and in vitro experimental model studies. [Abstract]2021 Jul:96:107600. PMID: 33798807 -
Int Immunopharmacol
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury. [Abstract]2019 Oct:75:105779. PMID: 31362164 -
Int J Mol Sci
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. [Abstract]2017 May 19;18(5):1063. PMID: 28534819
Selisistat purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 May 19;18(5):1063. [Abstract]
Inhibition of sirt1 and AMPK blocked Rb2-induced hepatic autophagy. HepG2 cells are pretreated with 50 µM Rb2 for 4 h in the presence or absence of the sirt1 inhibitor EX-528 (EX) and the specific AMPK inhibitor Compound C (CC), and then subjected to OA (1 mM for HepG2 and 2 mM for primary mouse hepatocytes) exposure for 12 h. For lipid content determination, intracellular TG are stained by Oil red O (ORO). ORO is then eluted with isopropanol and the optical absorbance of the eluate is measured
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Mol Neurobiol
Resveratrol Attenuates H2O2-induced Aging and Apoptosis in Mouse Hippocampal Neuron HT22 Cells by Activating Autophagy via the SIRT1/FoxO1 Signaling Pathway. [Abstract]2025 Nov 7;63(1):12. PMID: 41203934 -
Mol Neurobiol
Ginsenoside Rg1 Downregulates miR-9-5p Expression to Modulate SIRT1-Mediated Mitochondrial Dysfunction and Ameliorate Alzheimer's Disease. [Abstract]2025 Jun 6. PMID: 40478516 -
Mol Neurobiol
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ. [Abstract]2023 Aug;60(8):4795-4810. PMID: 37162725 -
Neurochem Int
DJ-1 activates the Atg5-Atg12-Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/reperfusion-induced inflammatory injury. [Abstract]2022 Jul:157:105341. PMID: 35429577 -
mBio
2026 Mar 18:e0248925. PMID: 41848315 -
Inflammation
Sirtuin1 Deficiency Could Exacerbate Melanocyte Apoptosis Under Endoplasmic Reticulum Stress. [Abstract]2025 Oct;48(5):3146-3155. PMID: 39921788 -
Front Pharmacol
Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation. [Abstract]2020 Sep 11:11:1315. PMID: 33041785 -
Front Pharmacol
Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway. [Abstract]2020 Mar 18:11:264. PMID: 32256355 -
Front Pharmacol
Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro. [Abstract]2018 Aug 3:9:854. PMID: 30123131
Selisistat purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Aug 3:9:854. [Abstract]
Western blotting and quantitative analysis of XBP-1 and ATF6 levels normalized to GAPDH in mice (n=6). Western blotting and quantitative analysis of P-Smad3 and ac-Smad3 levels normalized to T-Smad3 (n=6). I stands for ISO, G stands for GE, and E stands for Ex-527.
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Biogerontology
Empagliflozin improves kidney senescence induced by D-galactose by reducing sirt1-mediated oxidative stress. [Abstract]2023 Oct;24(5):771-782. PMID: 37227544 -
Chem Biol Interact
Sirtuin 1/3 regulates p53 deacetylation to inhibit iron poisoning-induced alveolar epithelial cell death and contributes to Rapamycin-mediated protection against limb ischemia/reperfusion-induced lung injury. [Abstract]2025 Nov 1:421:111756. PMID: 40992491 -
Toxicology
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells. [Abstract]2024 Aug:506:153861. PMID: 38866128 -
J Nutr Biochem
Treatment with butyrate alleviates dextran sulfate sodium and Clostridium difficile-induced colitis by preventing activity of Th17 cells via regulation of SIRT1/mTOR in mice. [Abstract]2023 Jan:111:109155. PMID: 36162566 -
J Nutr Biochem
Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. [Abstract]2022 Jan:99:108862. PMID: 34530111 -
Psychiatry Res
Running exercise alleviates depressive-like behaviors through the activation of PINK1-Parkin mediated mitophagy in mice exposed to chronic social defeat stress. [Abstract]2025 Oct:352:116714. PMID: 40912062 -
Molecules
20 (S)-Protopanaxadiol Alleviates DRP1-Mediated Mitochondrial Dysfunction in a Depressive Model In Vitro and In Vivo via the SIRT1/PGC-1α Signaling Pathway. [Abstract]2024 Oct 28;29(21):5085. PMID: 39519726 -
World J Diabetes
Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway. [Abstract]2024 Sep 15;15(9):1916-1931. PMID: 39280180 -
Molecules
Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway. [Abstract]2024 Jan 4;29(1):261. PMID: 38202844 -
Molecules
Melatonin Inhibits Apoptosis and Oxidative Stress of Mouse Leydig Cells via a SIRT1-Dependent Mechanism. [Abstract]2019 Aug 25;24(17):3084. PMID: 31450679 -
Biochim Biophys Acta Mol Basis Dis
USP47 alleviates metabolic-associated fatty liver disease by activating the PPARα signaling pathway through the stabilization of SIRT1. [Abstract]2026 Apr 1;1872(5):168232. PMID: 41930505 -
Food Sci Nutr
Nutritional Modulation of Melatonin-SIRT1 Signaling by Octanoic Acid-Rich Enteral Nutrition Protects Against Radiation-Induced Intestinal Injury. [Abstract]2026 Jan 27;14(1):e71465. PMID: 41607646 -
Food Sci Nutr
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism. [Abstract]2026 Jan 9;14(1):e71416. PMID: 41523277 -
J Mol Med (Berl)
Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis. [Abstract]2025 Dec 20;104(1):10. PMID: 41419644 -
Biochim Biophys Acta Mol Basis Dis
SIRT1-PINK1-Parkin axis orchestrated mitophagy and renal repair by dapagliflozin in diabetic nephropathy. [Abstract]2025 Oct 15;1872(2):168074. PMID: 41106506 -
Food Sci Nutr
Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD. [Abstract]2025 Aug 11;13(8):e70736. PMID: 40801050 -
Biochim Biophys Acta Mol Basis Dis
Dietary apigenin ameliorates obesity-related hypertension through TRPV4-dependent vasorelaxation and TRPV4-independent adiponectin secretion. [Abstract]2024 Dec;1870(8):167488. PMID: 39218272 -
Mol Med Rep
gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice. [Abstract]2024 Aug;30(2):133. PMID: 38818814 -
Mol Med Rep
NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria. [Abstract]2022 Mar;25(3):84. PMID: 35029280 -
Sci Rep
RANBP3 promotes mitophagy through the CCAR2/SIRT1 pathway to alleviate pyroptosis in macrophages in TBTB. [Abstract]2026 Jun 11. PMID: 42277087 -
Sci Rep
Morinda officinalis polysaccharides activate the SIRT1/PGC-1α pathway to reduce oxidative damage in Leydig TM3 cells. [Abstract]2026 Apr 9;16(1):16198. PMID: 41957157 -
Sci Rep
In vivo and in vitro investigations of schisandrin B against angiotensin II induced ferroptosis and atrial fibrosis by regulation of the SIRT1 pathway. [Abstract]2025 Feb 20;15(1):6200. PMID: 39979353 -
Exp Neurol
Biochanin A exerts neuroprotective effects in Parkinson's disease both in vivo and in vitro by improving mitochondrial dysfunction through the Sirt1 signaling pathway. [Abstract]2026 Apr:398:115636. PMID: 41483847 -
Int J Neuropsychopharmacol
Mechanism of the AMPK/SIRT1 pathway in gut dysbiosis-mediated postoperative cognitive dysfunction in aged mice. [Abstract]2025 Oct 1;28(10):pyaf066. PMID: 41031618 -
Exp Neurol
2025 Aug:390:115303. PMID: 40345568 -
Cancers (Basel)
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway. [Abstract]2023 Apr 23;15(9):2427. PMID: 37173894 -
Cancers (Basel)
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1. [Abstract]2023 Apr 20;15(8):2378. PMID: 37190306 -
Cancers (Basel)
Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells. [Abstract]2022 Jan 10;14(2):323. PMID: 35053490 -
Mol Cell Biochem
Decoding dexmedetomidine's multiple mechanisms in atherosclerosis: effects on lipid metabolism, inflammation, cholesterol efflux, and foam cell formation. [Abstract]2026 Mar 13. PMID: 41824202 -
J Dairy Sci
Salidroside protects bovine hepatocytes against fatty acid-induced lipid accumulation and inflammation by activating AMPK/SIRT1 pathway. [Abstract]2025 Sep;108(9):10136-10150. PMID: 40645487 -
Cell Signal
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis. [Abstract]2023 Oct:110:110801. PMID: 37433399 -
Mol Cell Biochem
Erythropoietin promotes energy metabolism to improve LPS-induced injury in HK-2 cells via SIRT1/PGC1-α pathway. [Abstract]2023 Mar;478(3):651-663. PMID: 36001204 -
J Cell Mol Med
Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level. [Abstract]2022 Aug;26(15):4216-4229. PMID: 35791579 -
J Cell Mol Med
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis. [Abstract]2022 Apr;26(7):1994-2009. PMID: 35174626 -
J Cell Mol Med
FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway. [Abstract]2021 Apr;25(7):3585-3600. PMID: 33751819 -
J Cell Mol Med
Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways. [Abstract]2020 Nov;24(21):12355-12367. PMID: 32961025 -
J Neurochem
Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy. [Abstract]2026 Jun;170(6):e70493. PMID: 42283221 -
J Inflamm Res
Protective Effects of CR6-Interacting Factor 1 Against Angiotensin II-Induced Atrial Fibrillation by Regulating the SIRT1/eNOS Signaling Pathway and Cardiomyocyte Remodeling. [Abstract]2026 Jun 10:19:596132. PMID: 42299155 -
J Inflamm Res
Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis. [Abstract]2025 Apr 23:18:5519-5531. PMID: 40297547 -
J Inflamm Res
Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx. [Abstract]2023 Feb 1:16:421-431. PMID: 36755970 -
Biomed Eng Online
Protective effects of wogonin on lipopolysaccharide-induced inflammation and apoptosis of lung epithelial cells and its possible mechanisms. [Abstract]2021 Dec 14;20(1):125. PMID: 34906140 -
J Inflamm Res
Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson's Disease. [Abstract]2021 Jul 8:14:3063-3075. PMID: 34267535 -
Neurochem Res
Electroacupuncture Promotes Synaptic Recovery After Cerebral Ischemia-Reperfusion by Activating SIRT1 to Inhibit the NF-κB Pathway and Regulate Astrocyte Phenotypic Transformation. [Abstract]2026 May 18;51(3):159. PMID: 42149357 -
Brain Res Bull
Morin alleviates sepsis-associated encephalopathy through inhibiting ferroptosis via SIRT1. [Abstract]2025 Dec:233:111638. PMID: 41241125 -
Brain Res Bull
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway. [Abstract]2025 Jul:227:111404. PMID: 40441663 -
Mol Nutr Food Res
Alpha-Linolenic Acid Supplementation Improves Testosterone Production in an Aged Breeder Rooster Model: Role of Mitochondrial Modulation and SIRT1 Activation. [Abstract]2024 Nov;68(22):e2400522. PMID: 39491816 -
Biomedicines
Medical Prospect of Melatonin in the Intervertebral Disc Degeneration through Inhibiting M1-Type Macrophage Polarization via SIRT1/Notch Signaling Pathway. [Abstract]2023 Jun 1;11(6):1615. PMID: 37371708 -
iScience
BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations. [Abstract]2020 Aug 21;23(8):101431. PMID: 32798974 -
Neurochem Res
Triptolide Improves Cognitive Dysfunction in Rats with Vascular Dementia by Activating the SIRT1/PGC-1α Signaling Pathway. [Abstract]2019 Aug;44(8):1977-1985. PMID: 31236795 -
Biosci Rep
MiR-155 is involved in major depression disorder and antidepressant treatment via targeting SIRT1. [Abstract]2018 Dec 21;38(6):BSR20181139. PMID: 30482883 -
Bioengineering (Basel)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells. [Abstract]2026 Feb 24;13(3):256. PMID: 41899787 -
BMC Complement Med Ther
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway. [Abstract]2022 Aug 9;22(1):213. PMID: 35945571 -
FASEB J
SENP3 Exacerbates Spinal Cord Injury by Increasing H6PD deSUMOylation to Promote Glycolysis. [Abstract]2026 Jun 15;40(11):e71995. PMID: 42247250 -
FASEB J
Ghrelin alleviates intestinal ischemia-reperfusion injury by activating the GHSR-1α/Sirt1/FOXO1 pathway. [Abstract]2024 Jun;38(11):e23681. PMID: 38814725 -
FASEB J
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. [Abstract]2022 Dec;36(12):e22672. PMID: 36440960 -
Biochim Biophys Acta Mol Cell Res
DDIT3/CHOP mediates the inhibitory effect of ER stress on chondrocyte differentiation by AMPKα-SIRT1 pathway. [Abstract]2022 Aug;1869(8):119265. PMID: 35381294 -
Biochim Biophys Acta Mol Cell Res
2021 Aug;1868(9):119074. PMID: 34087318 -
Biochim Biophys Acta Mol Cell Biol Lipids
2018 Jun;1863(6):595-603. PMID: 29522896
Selisistat purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jun;1863(6):595-603. [Abstract]
LC3 deacetylation levels after erythropoietin (EPO) treatment are detected in PA-treated cells that have been treated with or without the SIRT1 inhibitor EX-527.
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J Nutr
Zinc-Mediated Deacetylation of FXR Activates the ATGL Pathway to Reduce Hepatic Lipid Accumulation and Enhance Lipolysis in Yellow Catfish. [Abstract]2025 May;155(5):1350-1363. PMID: 40089111 -
Drug Dev Res
Tropisetron attenuates high glucose-induced oxidative stress and inflammation in ARPE-19 cells in vitro via regulating SIRT1/ROCK1 signaling. [Abstract]2024 Nov;85(7):e70002. PMID: 39381984 -
Front Biosci (Landmark Ed)
Dapagliflozin Attenuates Myocardial Inflammation and Apoptosis after Coronary Microembolization in Rats by Regulating the SIRT1/NF-κB Signaling Pathway. [Abstract]2025 Mar 18;30(3):27082. PMID: 40152380 -
Microbiol Spectr
L-Serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen. [Abstract]2024 Jan 19;12(3):e0322623. PMID: 38240573 -
ACS Pharmacol Transl Sci
Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway. [Abstract]2026 Apr 3;9(5):1134-1152. PMID: 42130718 -
Naunyn Schmiedebergs Arch Pharmacol
Genkwanin alleviates paraquat-induced acute lung injury by activating SIRT1-mediated Nrf2/HO-1 signaling pathway. [Abstract]2025 Oct 17. PMID: 41105248 -
Naunyn Schmiedebergs Arch Pharmacol
L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1. [Abstract]2025 May 6. PMID: 40328913 -
Naunyn Schmiedebergs Arch Pharmacol
Sappanone a alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis via activating the SIRT1/Nrf2 signaling pathway. [Abstract]2024 Nov;397(11):8759-8770. PMID: 38832987 -
Selisistat purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2023 Mar.
Selisistat (EX527) treatment significantly increases the levels of C-caspase3 and Bax but decreases the levels of Bcl-2, in 4-OI (4-Octyl Itaconate)-treated chondrocytes.
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Neurotox Res
Polydatin Prevents Neuroinflammation and Relieves Depression via Regulating Sirt1/HMGB1/NF-κB Signaling in Mice. [Abstract]2022 Oct;40(5):1393-1404. PMID: 35986876 -
Neurotox Res
Apelin-36 Protects HT22 Cells Against Oxygen-Glucose Deprivation/Reperfusion-Induced Oxidative Stress and Mitochondrial Dysfunction by Promoting SIRT1-Mediated PINK1/Parkin-Dependent Mitophagy. [Abstract]2021 Jun;39(3):740-753. PMID: 33580874 -
Cell Cycle
Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1. [Abstract]2020 Jul;19(13):1677-1695. PMID: 32453975 -
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J Orthop Surg Res
Pure platelet-rich plasma delays intervertebral disc degeneration by activating SIRT1-mediated autophagy in nucleus pulposus cells. [Abstract]2025 Aug 22;20(1):786. PMID: 40846953 -
Ren Fail
Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy. [Abstract]2021 Dec;43(1):128-140. PMID: 33427556 -
Exp Biol Med
Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction. [Abstract]2021 Mar;246(5):596-606. PMID: 33215523 -
Metab Brain Dis
Echinacoside protects against MPTP/MPP+-induced neurotoxicity via regulating autophagy pathway mediated by Sirt1. [Abstract]2019 Feb;34(1):203-212. PMID: 30426321
Selisistat purchased from MedChemExpress. Usage Cited in: Metab Brain Dis. 2019 Feb;34(1):203-212. [Abstract]
Western analysis of the protein expression of Sirt1, FoxO1 and LC3 protein in the PC12 with the treatment of MPP+, ECH and EX527.
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J Nat Prod
Dihydrotrichodimerol Purified from the Marine Fungus Acremonium citrinum Prevents NAFLD by Targeting PPARα. [Abstract]2023 May 26;86(5):1189-1201. PMID: 37083418 -
Proc Biol Sci
2023 Dec 6;290(2012):20232093. PMID: 38052245 -
Toxicol Appl Pharmacol
SIRT1 reduction contributes to doxorubicin-induced oxidative stress and meiotic failure in mouse oocytes. [Abstract]2023 Oct 1:476:116671. PMID: 37633598 -
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Peptides
Cholecystokinin regulates atrial natriuretic peptide secretion through activation of NOX4-Sirt1-LEF1 signaling in beating rat hypoxic atria. [Abstract]2024 Nov:181:171299. PMID: 39326462 -
Diabetes Metab Syndr Obes
GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway. [Abstract]2023 Aug 15:16:2433-2446. PMID: 37602204 -
Exp Cell Res
Inhibition of 14-3-3ε by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth. [Abstract]2022 Dec 15;421(2):113404. PMID: 36341908 -
J Cosmet Dermatol
2022 Mar;21(3):1163-1170. PMID: 33894036 -
Biochimie
SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells. [Abstract]2020 Mar;170:10-20. PMID: 31830513 -
Neuroscience
The protective effect of biochanin A on LPS/TNF-α-induced PD models is exerted by regulating ferroptosis through the Sirt1/Nrf2/GPX4 signaling pathway. [Abstract]2026 Jun 22:605:91-107. PMID: 41999934 -
BMC Neurosci
SRT1720 ameliorates LPS-induced depressive-like behaviors in mice and activates Parkin-mediated mitophagy. [Abstract]2025 Aug 30;26(1):56. PMID: 40885954 -
Cardiovasc Toxicol
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway. [Abstract]2022 Sep;22(9):842-857. PMID: 35809215 -
Mol Biol Rep
MicroRNA-124a/Sirtuin 1 pathway inhibits autophagy to promote hepatocyte apoptosis in acute-on-chronic liver failure. [Abstract]2025 Mar 15;52(1):314. PMID: 40088364 -
Food Chem Toxicol
Melatonin modulates the differentiation of neural stem cells exposed to manganese via SIRT1/β-catenin signaling. [Abstract]2024 Feb:184:114349. PMID: 38081531 -
Chin J Integr Med
Berberine Ameliorates Atherosclerosis by Promoting Mitochondrial Biogenesis via SIRT1/PGC-1α Signaling Pathway. [Abstract]2026 Apr 27. PMID: 42043671 -
J Steroid Biochem Mol Biol
Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation. [Abstract]2025 Mar:247:106669. PMID: 39736459 -
BMC Cardiovasc Disord
Resistance exercise promotes the resolution and recanalization of deep venous thrombosis in a mouse model via SIRT1 upregulation. [Abstract]2023 Jan 13;23(1):18. PMID: 36639616 -
J Pain Res
Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway. [Abstract]2019 Mar 4:12:879-890. PMID: 30881098 -
BMC Mol Cell Biol
2022 Dec 7;23(1):52. PMID: 36476345 -
Theriogenology
Oleuropein restores oocyte competence during SIRT1 inhibition via SIRT1/NRF2-mediated redox and metabolic reprogramming in porcine oocytes. [Abstract]2026 May:256:117873. PMID: 41698313 -
Int J Colorectal Dis
AQP3 mediates autophagy through SIRT1/p62 signal to alleviate intestinal epithelial cell damage caused by sepsis. [Abstract]2024 Dec 20;39(1):205. PMID: 39702605 -
Theriogenology
Melatonin alleviates oxidative stress and inflammation of Leydig cells of Min pig through SIRT1 pathway. [Abstract]2024 Nov 27:233:112-122. PMID: 39613495 -
Theriogenology
The ginsenoside Rh2 protects porcine oocytes against aging and oxidative stress by regulating SIRT1 expression and mitochondrial activity. [Abstract]2023 Apr 1:200:125-135. PMID: 36805249 -
Biomed Res Int
To Analyze the Mechanism of SalB Regulating SIRT1 to Inhibit NLRP3 and Its Ameliorative Effect on Tubulogastric Junction Tumor Lesions Complicated with Myocardial Injury. [Abstract]2022 Oct 14:2022:6560693. PMID: 36277894 -
BMC Immunol
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis. [Abstract]2021 May 27;22(1):34. PMID: 34044769 -
Gene
2024 Apr 5:901:148171. PMID: 38242372 -
Gene
Molecular cloning and characterization of Sirt1 and its role in the follicle of juvenile Chinese soft-shelled turtle (Pelodiscus sinensis). [Abstract]2023 Apr 15:860:147211. PMID: 36708847 -
Neuropeptides
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway. [Abstract]2021 Jun:87:102134. PMID: 33639357 -
Burns
Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation. [Abstract]2026 Jan 19;52(2):107872. PMID: 41579448 -
J Mol Histol
Evodiamine alleviates IL-1β-induced chondrocyte damage by regulating mitochondrial dysfunction via the SIRT1/PGC-1α pathway. [Abstract]2025 Nov 4;56(6):363. PMID: 41186656 -
J Mol Histol
Exendin-4 alleviates diabetic retinopathy by activating autophagy via regulation of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway. [Abstract]2025 Jun 28;56(4):210. PMID: 40580219 -
J Nat Med
Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1. [Abstract]2025 Mar;79(2):371-380. PMID: 39702722 -
Urolithiasis
Puerarin prevents calcium oxalate crystal-induced renal epithelial cell autophagy by activating the SIRT1-mediated signaling pathway. [Abstract]2022 Oct;50(5):545-556. PMID: 35913552 -
Acta Trop
Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein. [Abstract]2021 Aug:220:105961. PMID: 34010594 -
Thorac Cancer
Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro. [Abstract]2021 May;12(9):1415-1422. PMID: 33709560 -
Clin Exp Pharmacol Physiol
Cynomorium songaricum Rupr. Polysaccharide (CSP) Attenuates Diabetic Nephropathy by Activating AMPK/SIRT1 Signalling. [Abstract]2026 Jun;53(6):e70138. PMID: 42252812 -
Clin Exp Pharmacol Physiol
Ciliatoside A Improves Klebsiella pneumoniae-Induced Pneumonia by Modulating Mitochondrial Autophagy via the SIRT1/PINK1/Parkin Pathway. [Abstract]2026 May;53(5):e70125. PMID: 42026873 -
Clin Exp Pharmacol Physiol
Dihydromyricetin protects sevoflurane-induced mitochondrial dysfunction in HT22 hippocampal cells. [Abstract]2024 Sep;51(9):e13912. PMID: 39103220 -
Biochem Biophys Res Commun
Andrographolide improves the dysfunction of endothelial progenitor cells from angiotensin II-induced hypertensive mice through SIRT1 signaling. [Abstract]2023 Jan 29:642:11-20. PMID: 36543019 -
Biochem Biophys Res Commun
Atractylodin alleviates cancer anorexia-cachexia syndrome by regulating NPY through hypothalamic Sirt1/AMPK axis-induced autophagy. [Abstract]2022 Oct 15:625:154-160. PMID: 35963161 -
Clin Cosmet Investig Dermatol
Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent Autophagy. [Abstract]2022 Aug 2;15:1499-1508. PMID: 35941856 -
Biochem Biophys Res Commun
Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. [Abstract]2020 Jul 12;528(1):7-13. PMID: 32448510 -
J Mol Neurosci
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis. [Abstract]2021 Apr;71(4):691-701. PMID: 32910356 -
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J Food Biochem
Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells by regulating miR-34a/SIRT1 to reduce acetylation. [Abstract]2021 Feb;45(2):e13623. PMID: 33491221 -
Exp Ther Med
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells. [Abstract]2026 Mar 19;31(5):141. PMID: 41929533 -
Exp Ther Med
Nicotinamide ribose ameliorates myocardial ischemia/reperfusion injury by regulating autophagy and regulating oxidative stress. [Abstract]2024 Mar 7;27(5):187. PMID: 38533432 -
Exp Ther Med
Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. [Abstract]2023 Jul 24;26(3):433. PMID: 37602306 -
Exp Ther Med
Propofol reduces lipopolysaccharide‑induced cardiomyocyte injury in sepsis by activating SIRT1‑mediated autophagy. [Abstract]2023 Mar 14;25(4):187. PMID: 37021065 -
Exp Ther Med
Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. [Abstract]2020 Dec;20(6):262. PMID: 33199987 -
Physiol Rep
N-butylphthalide (NBP) ameliorated ischemia/reperfusion-induced skeletal muscle injury in male mice via activating Sirt1/Nrf2 signaling pathway. [Abstract]2024 Dec;12(23):e70149. PMID: 39614673 -
Folia Histochem Cytobiol
Electroacupuncture ameliorates depressive-like behaviors by activating Sirt1 to enhance oligodendrocyte differentiation and myelination in the prefrontal cortex of rats. [Abstract]2025 Sep 24. PMID: 40990232 -
Biochem Genet
ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1. [Abstract]2024 Aug;62(4):3245-3259. PMID: 38214831 -
Biol Pharm Bull
Ginsenoside Rb1 Alleviates Asthma Inflammation by Regulating Mitochondrial Dysfunction through SIRT1/PGC-1α and PI3K/AKT Pathways. [Abstract]2025;48(11):1741-1752. PMID: 41242748 -
Biol Pharm Bull
5-Demethylnobiletin Ameliorates Isoproterenol-Induced Cardiac Fibrosis and Apoptosis by Repressing the Sirt1/FOXO3a/NF-κB and Wnt/β-Catenin Pathways. [Abstract]2024;47(10):1774-1785. PMID: 39477471 -
Biol Pharm Bull
The Effect of Resveratrol in Sirt1/CST Pathway to Inhibit TNF-α Induced Inflammatory Response in Rat Primary Fibroblast-Like Synoviocytes. [Abstract]2023 Jul;46(11):1592-1600. PMID: 37914362 -
J Cardiothorac Surg
Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway. [Abstract]2023 Sep 26;18(1):265. PMID: 37752609 -
Tohoku J Exp Med
Dapagliflozin Alleviates Non-Alcoholic Fatty Liver Disease in Mice by Inhibiting Ferroptosis Through Activating the SIRT1/Nrf2 Pathway. [Abstract]2026 May 14. PMID: 42128820 -
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bioRxiv
Radiation synergizes with BET inhibition to stimulate durable, systemic anti-tumor immunity in murine cancer models. [Abstract]2026 Feb 18:2026.02.16.706212. PMID: 41757027 -
Biomed Pharmacother
Vitamin D and SIRT1 activator SRT2104 cooperate in antiproliferative activity in lung cancer through ferroptosis induction. [Abstract]2025 Sep:190:118391. PMID: 40768932 -
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Biomed Pharmacother
Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway. [Abstract]2025 Aug:189:118316. PMID: 40618584 -
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Biomed Pharmacother
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway. [Abstract]2024 Aug:177:117008. PMID: 38901196 -
Biomed Pharmacother
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy. [Abstract]2023 Oct:166:115342. PMID: 37633053 -
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Biomed Pharmacother
Ethyl caffeate inhibits macrophage polarization via SIRT1/NF-κB to attenuate traumatic heterotopic ossification in mice. [Abstract]2023 May:161:114508. PMID: 37002582 -
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Biomed Pharmacother
Jiedu Tongluo Baoshen formula enhances renal tubular epithelial cell autophagy to prevent renal fibrosis by activating SIRT1/LKB1/AMPK pathway. [Abstract]2023 Apr:160:114340. PMID: 36738503 -
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Evid Based Complement Alternat Med
Resveratrol Inhibits Insulin-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Activating SIRT1. [Abstract]2022 Nov 28:2022:8537881. PMID: 36479179 -
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Oxid Med Cell Longev
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1 α Axis. [Abstract]2022 Oct 3:2022:1231970. PMID: 36225175 -
Oxid Med Cell Longev
Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1 α/XBP1s/CHOP Pathway in Vascular Dementia Rats. [Abstract]2022 Aug 16:2022:6664990. PMID: 36017237 -
Oxid Med Cell Longev
Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage. [Abstract]2022 Jul 9:2022:9069825. PMID: 35855863 -
Allergol Immunopathol
Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. [Abstract]2022 Jul 1;50(4):115-123. PMID: 35789410 -
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Biomed Pharmacother
A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation. [Abstract]2022 Jun;150:113071. PMID: 35658237 -
Bioengineered
Transcriptional factor 3 binds to sirtuin 1 to activate the Wnt/β-catenin signaling in cervical cancer. [Abstract]2022 May;13(5):12516-12531. PMID: 35587604 -
Environ Toxicol
Resveratrol reduces DRP1-mediated mitochondrial dysfunction via the SIRT1-PGC1α signaling pathway in manganese-induced nerve damage in mice. [Abstract]2022 Feb;37(2):282-298. PMID: 34738708 -
Biomed Pharmacother
Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling. [Abstract]2021 Aug:140:111693. PMID: 34029951 -
Oxid Med Cell Longev
Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control. [Abstract]2021 Feb 27:2021:6659240. PMID: 33728025 -
Oxid Med Cell Longev
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice. [Abstract]2021 Jan 19:2021:6610543. PMID: 33542782 -
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J BUON
2020 Nov-Dec;25(6):2665-2671. PMID: 33455111 -
Oxid Med Cell Longev
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway. [Abstract]2020 May 16:2020:6384803. PMID: 32509148 -
Biomed Pharmacother
2019 Oct:118:109227. PMID: 31351433 -
Oxid Med Cell Longev
Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway. [Abstract]2019 Sep 12:2019:5276096. PMID: 31612074 -
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Oncotarget
Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. [Abstract]2017 Apr 18;8(32):52783-52791. PMID: 28881770
Selisistat purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Apr 18;8(32):52783-52791. [Abstract]
Immunoblot analysis of p-AKT (Ser473) and LC3-II in cells treated with 50 nM of TCO for 24 h in the presence and absence of EX-527.
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (402.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 10 mg/mL (40.21 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (40.21 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protokoll
The immortal mouse macrophage cell line RAW264.7 are used. Cells are seeded in 96-well dishes at a density of 3 × 103 cells/cm2 and treated with high glucose at the concentrations of 5.6, 11.1, 25 and 30 mM, alone or with SRT1720 (1 μM) or Selisistat(10 μM) for 24 h. The stock solution of SRT1720 or Selisistat is prepared by dissolving each of them (in powder form) respectively in DMSO yielding a concentration of 100 μM and then stored at -80°C. MTT solution (0.5 mg/mL) is then added to each well and cells are incubated for 4 h at 37°C in a 5% CO2 incubator. Subsequently, the supernatant is removed, the formation of farmazan is solubilized with DMSO and measured at 540 nm with a Bio-Rad Model 680 Plate Reader[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice[3] Mice are injected with Resveratrol (RSV) 30mg/kg (4 mL/kg) or equivalent volume of DMSO (Vehicle) (4 mL/kg) intraperitoneally 18 hours pre-sepsis. This dose of RSV in mice is as per documented literature. In one group of mice, RSV pre-treated mice receive Selisistat (10 mg/kg intraperitoneally; 4mL/kg, Vehicle: DMSO) within 10 minutes of cecal ligation and puncture.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014;23(11):2995-3007. [Content Brief]
[2]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50(5):1086]. J Med Chem. 2005;48(25):8045-8054. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 4.0207 mL | 20.1037 mL | 40.2075 mL | 100.5187 mL |
| 5 mM | 0.8041 mL | 4.0207 mL | 8.0415 mL | 20.1037 mL | |
| 10 mM | 0.4021 mL | 2.0104 mL | 4.0207 mL | 10.0519 mL | |
| 15 mM | 0.2680 mL | 1.3402 mL | 2.6805 mL | 6.7012 mL | |
| 20 mM | 0.2010 mL | 1.0052 mL | 2.0104 mL | 5.0259 mL | |
| 25 mM | 0.1608 mL | 0.8041 mL | 1.6083 mL | 4.0207 mL | |
| 30 mM | 0.1340 mL | 0.6701 mL | 1.3402 mL | 3.3506 mL | |
| 40 mM | 0.1005 mL | 0.5026 mL | 1.0052 mL | 2.5130 mL | |
| DMSO | 50 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0104 mL |
| 60 mM | 0.0670 mL | 0.3351 mL | 0.6701 mL | 1.6753 mL | |
| 80 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2565 mL | |
| 100 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0052 mL |
Selisistat Related Classifications
HY-15452 Related Classifications
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