Abd110
Based on 1 Customer Validation
Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs.
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- Reinheit: 98.67%
- CAS. Nr.: 3021581-79-0
- Formel: C41H42N8O7S
- Molecular Weight:790.89
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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ATR |
Cereblon |
Abd110 (compound 42i; 0.5-2 μM; 24 h) selectively degrades ATR through the proteasome, dependent on the E3 ubiquitin ligase component cereblon, and without affecting the associated kinases ATM and DNA-PKcs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MIA PaCa-2 cells
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Concentration:0.5 μM, 1 μM, and 2 μM
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Incubation Time:24 h
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Result:Decreased ATR and p-ATR levels without affecting related checkpoint kinases.
Chemical Information
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CAS. Nr. 3021581-79-0
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Appearance Solid
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Molecular Weight 790.89
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Formel C41H42N8O7S
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Color Light yellow to yellow
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SMILES
O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (126.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.2644 mL | 6.3220 mL | 12.6440 mL | 31.6100 mL |
| 5 mM | 0.2529 mL | 1.2644 mL | 2.5288 mL | 6.3220 mL | |
| 10 mM | 0.1264 mL | 0.6322 mL | 1.2644 mL | 3.1610 mL | |
| 15 mM | 0.0843 mL | 0.4215 mL | 0.8429 mL | 2.1073 mL | |
| 20 mM | 0.0632 mL | 0.3161 mL | 0.6322 mL | 1.5805 mL | |
| 25 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.2644 mL | |
| 30 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL | |
| 40 mM | 0.0316 mL | 0.1580 mL | 0.3161 mL | 0.7902 mL | |
| 50 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.6322 mL | |
| 60 mM | 0.0211 mL | 0.1054 mL | 0.2107 mL | 0.5268 mL | |
| 80 mM | 0.0158 mL | 0.0790 mL | 0.1580 mL | 0.3951 mL | |
| 100 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3161 mL |
Abd110 Related Classifications
HY-157767 Related Classifications
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