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Art. -Nr.: HY-183653

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AK442

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research.

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CAS. Nr.: 3062376-05-7
Formel: C₃₅H₄₀ClN₉O₄
Molecular Weight:686.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AK442 Chemical Structure

CAS. Nr.: 3062376-05-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research^[1].

IC₅₀ & Target^[1]

PRMT4

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

AK442 (10 μM; 6.5 h) binds to PRMT4 in MDA-MB-231 cells and increases the thermal stability of PRMT4 by 2 °C compared with the DMSO control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3062376-05-7
Molecular Weight 686.20
Formel C₃₅H₄₀ClN₉O₄
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(CCNCC4=CC(C5=CC=C(C=C5)Cl)=CC=C4)CCNC(NCC6=CC=CC=C6)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kulkarni AS, et al. Tailoring PRMT Inhibition: Shifting PRMT7 Selectivity to PRMT4 through "T-Shape" Strategy and "Linker-Specific" Preferences. J Med Chem. 2026 May 14;69(9):9977-9990. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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AK442

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AK442 Related Classifications

HY-183653 Related Classifications