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Art. -Nr.: HY-147906

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Anticancer agent 71

Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.

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CAS. Nr.: 2453228-45-8
Formel: C₁₈H₁₃ClF₃N₅O
Molecular Weight:407.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 71 Chemical Structure

CAS. Nr.: 2453228-45-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells^[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest^[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SW480 and PC3 cells
Concentration:

0.1, 1, 12.5, 25 and 50 μM
Incubation Time:

24 hours
Result:

Inhibited with IC₅₀ values of 11.08 and 17.39 μM for SW480 and PC3 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

SW480 cells
Concentration:

11.08 μM
Incubation Time:

24 hours
Result:

The cell population percent at G2/M phase increased to 45.3%.

Apoptosis Analysis^[1]

Cell Line:

SW480 cells
Concentration:

11.08 μM
Incubation Time:

24 hours
Result:

The percentage of cells in early and late apoptosis was recorded as 5.69% and 3.52%, respectively.

Western Blot Analysis^[1]

Cell Line:

SW480 cells
Concentration:

11.08 μM
Incubation Time:

24 hours
Result:

The expression of antiapoptotic protein Bcl-2 decreased and the expression of Pro apoptotic Bax increased.

Chemical Information

CAS. Nr. 2453228-45-8
Molecular Weight 407.78
Formel C₁₈H₁₃ClF₃N₅O
SMILES

NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kilic-Kurt Z, et al. Synthesis and anticancer activity of some pyrimidine derivatives with aryl urea moieties as apoptosis-inducing agents. Bioorg Chem. 2020 Aug;101:104028. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Anticancer agent 71

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