Crocetin
Based on 3 publication(s) in Google Scholar
Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia.
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- Reinheit: 98.07%
- CAS. Nr.: 27876-94-4
- Formel: C20H24O4
- Molecular Weight:328.40
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Crocetin
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Biologische Aktivität
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NMDA Receptor |
COX-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
5.99 μM
Compound: 18
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Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
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[PMID: 23305920] |
Crocetin (1-100 μM, 24 h) inhibits COX-2 expression in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:1, 10, 50 and 100 μM
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Incubation Time:24 h
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Result:Reduced COX-2 mRNA levels.
Crocetin (20 mg/kg, p.o., 1 h before ischemia) inhibits retinal ischemic damage in ischemia/reperfusion-induced mice models[2].
Crocetin (25 mg/mL, p.o., daily) delays brain and body aging in aged C57BL/6J mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Methylcholanthrene- (MCA)-induced uterine cervix tumor mice models[1]
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Dosage:10, 20 and 40 mg/kg
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Administration:Orally administration, twice a day for 35 days
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Result:Decreased MDA levels.
Decreased PMNs activity.
Reduced IL-1β, TNF-α and iNOS levels.
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Animal Model:Ischemia/reperfusion-induced mice models[2]
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Dosage:20 mg/kg
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Administration:Orally administration, 1 h before ischemia
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Result:Prevented the reduction in IPL thickness.
Prevented the induction of cell apoptosis.
Inhibited functional damage and DNA oxidation in the retina.
Prevented the activation of MAPK and redox-sensitive transcription factors in the retina.
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Animal Model:Aged C57BL/6J mice[3]
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Dosage:25 mg/mL
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Administration:Orally administration, daily
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Result:Increased ATP and NAD+ levels.
Upregulated the electron transport chain to yield more energy.
Restored the ETC function of mitochondria.
Attenuated the basal level of oxidative stress.
Chemical Information
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CAS. Nr. 27876-94-4
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Appearance Solid
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Molecular Weight 328.40
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Formel C20H24O4
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Color Yellow to orange
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SMILES
O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O
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Synonyms
Transcrocetin; trans-Crocetin
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (3)
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Journal Impact Factor
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Most Recent
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Int J Pharm X
RGD peptide-functionalized micelles loaded with crocetin ameliorate doxorubicin-induced cardiotoxicity. [Abstract]2025 Feb 26:9:100326. PMID: 40103672 -
Int Immunopharmacol
Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]2026 Mar 1:172:116231. PMID: 41576568 -
J Phys Chem B
2026 Jan 8;130(1):205-214. PMID: 41404815
Lösungsmittel & Löslichkeit
DMSO : 20 mg/mL (60.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC/saline water
Solubility: 10 mg/mL (30.45 mM); Suspended solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Chen B, et al. Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. Biomed Res Int. 2015;2015:829513. [Content Brief]
[2]. Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. Eur J Pharmacol. 2013 Mar 5;703(1-3):1-10. [Content Brief]
[3]. Choudhary S, et al. Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice. ACS Pharmacol Transl Sci. 2024 Sep 11;7(10):3017-3033. [Content Brief]
[4]. Lautenschläger M, et al. Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0451 mL | 15.2253 mL | 30.4507 mL | 76.1267 mL |
| 5 mM | 0.6090 mL | 3.0451 mL | 6.0901 mL | 15.2253 mL | |
| 10 mM | 0.3045 mL | 1.5225 mL | 3.0451 mL | 7.6127 mL | |
| 15 mM | 0.2030 mL | 1.0150 mL | 2.0300 mL | 5.0751 mL | |
| 20 mM | 0.1523 mL | 0.7613 mL | 1.5225 mL | 3.8063 mL | |
| 25 mM | 0.1218 mL | 0.6090 mL | 1.2180 mL | 3.0451 mL | |
| 30 mM | 0.1015 mL | 0.5075 mL | 1.0150 mL | 2.5376 mL | |
| 40 mM | 0.0761 mL | 0.3806 mL | 0.7613 mL | 1.9032 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6090 mL | 1.5225 mL | |
| 60 mM | 0.0508 mL | 0.2538 mL | 0.5075 mL | 1.2688 mL |
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