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Art. -Nr.: HY-169078

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ML234

ML234 is a dual inhibitor against EZH2/LSD1 with IC₅₀ values of 0.09 and 0.12 μM, respectively. ML234 displays an excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3 and 22RV1. ML234 suppresses the tumor growth in the 22RV1 xenograft mouse model. ML234 is promising for research of anticancer agents in prostate cancer.

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CAS. Nr.: 3068378-07-1
Formel: C₄₃H₅₈N₄O₆
Molecular Weight:726.94

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ML234 Chemical Structure

CAS. Nr.: 3068378-07-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
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Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	GI₅₀	3.96 μM Compound: 9j; ML234	Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay	[PMID: 39196854]
LNCaP	GI₅₀	1.63 μM Compound: 9j; ML234	Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay	[PMID: 39196854]
PC-3	GI₅₀	1.04 μM Compound: 9j; ML234	Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay	[PMID: 39196854]

Chemical Information

CAS. Nr. 3068378-07-1
Molecular Weight 726.94
Formel C₄₃H₅₈N₄O₆
SMILES

CC(C(C(NCC1=C(C=C(NC1=O)C)C)=O)=CC(C2=CC=C([C@@H]3C[C@H]3N(C(OC(C)(C)C)=O)CC4CCOCC4)C=C2)=C5)=C5N(CC)C6CCOCC6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Le M, et al. Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer. J Med Chem. 2024 Sep 12;67(17):15586-15605. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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ML234

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ML234 Related Classifications

HY-169078 Related Classifications