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Art. -Nr.: HY-170674A

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ND-L11B TFA

ND-L11B TFA is an NSD2 degrader with a K_d value of 8.77 μM, degrading the NSD2-long and RE-IIBP isoforms in multiple myeloma cells with DC₅₀ values of 1.48 μM and 0.8 μM, respectively. ND-L11B TFA reduces H3K36me2 levels and inhibits the proliferation of multiple myeloma cells. ND-L11B TFA serves as a starting point for the further development of NSD2-targeted compounds and is also a chemical knockdown tool for elucidating the multiple functions of NSD2 isoforms. ND-L11B TFA can be used for research on multiple myeloma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₉H₅₂F₆N₁₀O₄
Molecular Weight:838.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

ND-L11B TFA Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

NSD2

8.77 μM (Kd)

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancer

ND-L11B TFA (0.09-5.0 μM; 6-48 h) simultaneously degrades both NSD2-long and RE-IIBP isoforms in KMS11 multiple myeloma cells, with DC₅₀ values of 1.48 μM and 0.80 μM, respectively, and induces time-dependent NSD2 degradation from 6 to 48 h^[1].
ND-L11B TFA (0.63-2.50 μM for KMS11 cells; 2.0-8.0 μM for 22RV1 cells) downregulates H₃K₃₆ methylation levels in KMS11 multiple myeloma cells and 22RV1 prostate cancer cells^[1].
ND-L11B TFA (12-day exposure of KMS11 cells; 8-day exposure of 293T cells) potently inhibits the proliferation of KMS11 multiple myeloma cells with an IC₅₀ of 0.90 μM, while showing very low cytotoxicity against non-malignant human embryonic kidney 293T cells (IC₅₀ > 100 μM)^[1].
ND-L11B TFA (1.25-2.50 μM; 2 days) downregulates the expression of NSD2-regulated cancer-related genes in KMS11 multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

0.09, 0.13, 0.20, 0.29, 0.44, 0.66, 0.99, 1.48, 2.22, 3.33, 5.0 μM; 5 μM (time-dependent assay)
Incubation Time:

6, 12, 24, 36, 48 h (5 μM concentration)
Result:

Induced simultaneous concentration-dependent degradation of NSD2-long and RE-IIBP isoforms, with DC₅₀ values of 1.48 μM (NSD2-long) and 0.80 μM (RE-IIBP), and a maximum degradation (D_max) of approximately 80%.
Induced time-dependent degradation of NSD2 protein over 6 to 48 hours.

Real Time qPCR^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

1.25, 2.50 μM
Incubation Time:

2 days
Result:

Downregulated the expression of NSD2-regulated oncogenes and cancer-related genes including JAM2, MET, PAK1, RRAS2, BACE2, CA2, IGF2BP2, and CR2.

Related Protocols :

Chemical Information

Molecular Weight 838.89
Formel C₃₉H₅₂F₆N₁₀O₄
SMILES

O=C(NCCCCCCCCCCCN)COC1=CC(C2=NC=C(N3C[C@](CC(F)F)(N)CCC3)C(CN4C=NC5=C(N)N=CN=C45)=C2)=CC=C1F.O=C(O)C(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hu L, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. European journal of medicinal chemistry. 2025 Feb 05;283:117179. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
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ND-L11B TFA

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ND-L11B TFA Related Classifications

HY-170674A Related Classifications

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