Art. -Nr.: HY-176166

PD-M6

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PD-M6 is a mTOR PROTAC degrader (DC₅₀: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer.
(Pink: mTOR ligand (HY-B0795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W008296)).

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Reinheit: 98.17%
CAS. Nr.: 3058330-82-5
Formel: C₃₀H₃₉N₉O₆
Molecular Weight:621.69

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PD-M6 Chemical Structure

CAS. Nr.: 3058330-82-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PD-M6 is a mTOR PROTAC degrader (DC₅₀: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer^[1]. (Pink: mTOR ligand (HY-B0795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W008296)).

Alle mTOR Isoform-spezifische Produkte anzeigen :

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

PD-M6 (0.001-10 μM; 4-24 h) induces dose- and time-dependent degradation of mTOR in HeLa cells, with a DC₅₀ of 4.8 μM^[1].
PD-M6 inhibits the proliferation of HeLa, MCF-7 and HepG2 cancer cells, with IC₅₀ values of 11.3 μM, 2.58 μM and 3.23 μM, respectively^[1].
PD-M6 (0.1-10 μM; 4 days) inhibits long-term colony formation of HeLa cells^[1].
PD-M6 (10 μM) inhibits the migration of HeLa cells with an inhibition rate of over 50%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0.001-10 μM
Incubation Time:

4 h, 12 h, 24 h
Result:

Induced a dose-dependent reduction in mTOR levels, with significant degradation observed at 1 μM and maximum degradation (~90%) at 10 μM after 12 h.
Achieved a DC50 for mTOR degradation of 4.8 μM.
Reduced mTOR levels by ~50% at 4 h and ~90% at 24 h at 10 μM.

Cell Proliferation Assay^[1]

Cell Line:

HeLa cells
Concentration:

0.1-10 μM
Incubation Time:

4 days
Result:

Reduced HeLa cell colony formation in a concentration-dependent manner, with nearly 90% suppression of proliferation observed at 10 μM.

Chemical Information

CAS. Nr. 3058330-82-5
Appearance Solid
Molecular Weight 621.69
Formel C₃₀H₃₉N₉O₆
Color Light yellow to yellow
SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (160.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6085 mL

8.0426 mL

16.0852 mL

5 mM

0.3217 mL

1.6085 mL

3.2170 mL

10 mM

0.1609 mL

0.8043 mL

1.6085 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhu L, et al. Reversing an agonist into an inhibitor: Development of mTOR degraders. Eur J Med Chem. 2025;294:117774. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6085 mL	8.0426 mL	16.0852 mL	40.2130 mL
	5 mM	0.3217 mL	1.6085 mL	3.2170 mL	8.0426 mL
	10 mM	0.1609 mL	0.8043 mL	1.6085 mL	4.0213 mL
	15 mM	0.1072 mL	0.5362 mL	1.0723 mL	2.6809 mL
	20 mM	0.0804 mL	0.4021 mL	0.8043 mL	2.0106 mL
	25 mM	0.0643 mL	0.3217 mL	0.6434 mL	1.6085 mL
	30 mM	0.0536 mL	0.2681 mL	0.5362 mL	1.3404 mL
	40 mM	0.0402 mL	0.2011 mL	0.4021 mL	1.0053 mL
	50 mM	0.0322 mL	0.1609 mL	0.3217 mL	0.8043 mL
	60 mM	0.0268 mL	0.1340 mL	0.2681 mL	0.6702 mL
	80 mM	0.0201 mL	0.1005 mL	0.2011 mL	0.5027 mL
	100 mM	0.0161 mL	0.0804 mL	0.1609 mL	0.4021 mL

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PD-M6

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Pain-Related Compound Library

PROTAC Library

Cell Death Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle mTOR Isoform-spezifische Produkte anzeigen

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PD-M6

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Pain-Related Compound Library

PROTAC Library

Cell Death Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle mTOR Isoform-spezifische Produkte anzeigen

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PD-M6 Related Classifications

HY-176166 Related Classifications