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Art. -Nr.: HY-181165

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SB2960

SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human K_D of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection.

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CAS. Nr.: 3111225-79-4
Formel: C₃₄H₃₁F₃N₈O₃
Molecular Weight:656.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

SB2960 Chemical Structure

CAS. Nr.: 3111225-79-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

RACK1

SARS-CoV-2

Alle PKC Isoform-spezifische Produkte anzeigen :

In Vitro

SB2960 (1.2-100 μM) induces stress granule formation in Vero cells with an EC₅₀ of 12.31 μM and reduces SARS-CoV-2 N protein levels in a dose-dependent manner^[1].
SB2960 (0.2-100 μM) demonstrates broad-spectrum antiviral activity against multiple RNA viruses in Vero, Calu-3, and Huh7 cells with IC₅₀ values between 3.01 and 5.45 μM^[1].
SB2960 (20 μM; 24 h) modulates antiviral gene expression in G3BP1-GFP U-2 OS cells treated with poly(I:C)^[1].
SB2960 (0-30 μM) synergizes with Remdesivir (HY-104077) and Nirmatrelvir (HY-138687) against SARS-CoV-2 in Vero cells with high ZIP synergy scores^[1].
SB2960 (0.39-700 μM; 24 h) exhibits low cytotoxicity in Vero and G3BP1-GFP U-2 OS cells with a CC₅₀ > 100 μM^[1].
SB2960 (20 μM; 24 h) increases the thermal stability of RACK1 in Vero and G3BP1-GFP U-2 OS cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Vero and G3BP1-GFP U-2 OS cells
Concentration:

40 μM (CETSA)
Incubation Time:

2 h (CETSA)
Result:

Increased the thermal stability of RACK1, with a higher melting temperature (Tm) compared to DMSO-treated cells.

Real Time qPCR^[1]

Cell Line:

G3BP1-GFP U-2 OS cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Enhanced IFN-β expression in poly(I:C)-stimulated cells while attenuating RIG-I, ISG56, and RANTES expression.

Chemical Information

CAS. Nr. 3111225-79-4
Molecular Weight 656.66
Formel C₃₄H₃₁F₃N₈O₃
SMILES

CC1(C)OC2=CC(N3CCN(C(C4=NC=CN4C)=O)CC3)=C(NC(C5=NC=CC=C5)=O)C=C2C6=C1C=NN6C7=CC=C(C(F)(F)F)C=C7
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Byun WG, et al. Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules. Adv Sci (Weinh). Published online January 14, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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SB2960

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