Art. -Nr.: HY-N7073

Silymarin

11 Cited Publications

Kundenbewertung

Based on 11 publication(s) in Google Scholar

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (M^pro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research.

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Reinheit: 84.0%
CAS. Nr.: 65666-07-1

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Silymarin Chemical Structure

CAS. Nr.: 65666-07-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Silymarin (0-120 μg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 μg/ml silymarin, 71.5% at 40 μg/ml, 59.8% at 60 μg/ml, 44.5% at 80 μg/ml, 35.3% at 100 μg/ml and 33.9% at 120 μg/ml^[1].
Silymarin (40-80 μg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 μg/ml and 21.7% at 80 μg/ml,respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

AGS cells
Concentration:

20 µg/ml, 40 µg/ml, 80 µg/ml, 100 µg/ml and 120 µg/ml
Incubation Time:

24 hours
Result:

Indicated a significant concentration-dependent inhibitory effect on AGS cells starting at 20 µg/ml.

In Vivo

Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED₅₀) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 65666-07-1
Appearance Solid
Color Light yellow to yellow
SMILES

[Silymarin]
Structure Classification
- Others
Initial Source
- Plants
- Compositae
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (11)

All In Vivo Efficacy StudyBio/Physico-chemical AssayHistological Imaging/Staining

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Journal Impact Factor

J Ethnopharmacol

Yin-chen Wu-ling powder inhibits MAPKs/CXCL1/CXCR2-induced neutrophil infiltration to alleviate LPS/D-GalN-induced acute liver failure. [Abstract]

2025 May 12:119957. PMID: 40368257

Silymarin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 May 12:119957. [Abstract]

Silymarin (80 mg/kg; i.g.) increased the survival rate of ALF (acute liver failure) mice induced by LPS/D-GalN to nearly 40%.

Silymarin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 May 12:119957. [Abstract]

Silymarin (80 mg/kg; i.g.) treatment significantly reduced serum ALT and AST levels in ALF (acute liver failure) mice induced by LPS/D-GalN compared to the ALF group.

Silymarin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 May 12:119957. [Abstract]

Silymarin (80 mg/kg; i.g.) decreased hepatocyte death and infiltrated blood cells in ALF (acute liver failure) mice induced by LPS/D-GalN.

Silymarin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 May 12:119957. [Abstract]

Silymarin (80 mg/kg; i.g.) treatment produced a decrease in MDA and an increase in CAT activity in the liver tissue of ALF (acute liver failure) mice induced by LPS/D-GalN.
Int J Mol Sci

Dual Targeting of HIF-1α and DLL4 by Isoxanthohumol Potentiates Immune Checkpoint Blockade. [Abstract]

2026 Feb 5;27(3):1576. PMID: 41683994
Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845
Molecules

SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome. [Abstract]

2021 Mar 5;26(5):1409. PMID: 33807773

Silymarin purchased from MedChemExpress. Usage Cited in: Molecules. 2021 Mar 5;26(5):1409. [Abstract]

Inhibition of M^pro (SARS-CoV-2 main protease) by Silymarin (0-100 mg/L).
Naunyn Schmiedebergs Arch Pharmacol

β-sitosterol attenuates hepatic lipid accumulation and fibrosis via NLRP3 signaling in MASH mice. [Abstract]

2025 Oct 2. PMID: 41037128
Naunyn Schmiedebergs Arch Pharmacol

Silymarin ameliorates peritoneal fibrosis by inhibiting the TGF-β/Smad signaling pathway. [Abstract]

2023 Oct;396(10):2379-2391. PMID: 37052642

Silymarin purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2379-2391. [Abstract]

Silymarin (SM) (12.5-50 mg/kg; i.g.; once daily for 4 weeks) considerably decreased peritoneal thickness and collagen fiber deposition in peritoneal fibrosis (PF) mice.
J Bioenerg Biomembr

Fisetinidin chloride ameliorates carbon tetrachloride-induced hepatotoxicity in HepaRG cells. [Abstract]

2025 Oct 28. PMID: 41148503
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Oncol Lett

Silymarin induces multiple myeloma cell apoptosis by inhibiting the JAK2/STAT3 signaling pathway. [Abstract]

2025 Jul 4;30(3):426. PMID: 40688586
Biomed Chromatogr

In-depth investigation of the Silymarin effect on the pharmacokinetic parameters of sofosbuvir, GS-331007 and ledipasvir in rat plasma using LC-MS. [Abstract]

2022 Sep;36(9):e5427. PMID: 35708053
Indian J Exp Biol

2022 Dec.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 3 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 2.5 mg/mL; Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Féher J, et al. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7. [Content Brief]

[2]. Sung-Hyun Kim, et al.Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells. Oncol Rep. 2019 Nov;42(5):1904-1914. [Content Brief]

[3]. Mina Khoshnoodi, et al. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015 May;53(5):739-45. [Content Brief]

[4]. Anna Maria Sardanelli, et al. SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome. Molecules 2021, 26(5), 1409.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Silymarin

11 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Silymarin

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Silymarin Related Classifications

HY-N7073 Related Classifications