2. Epigenetics
  3. Epigenetic Reader Domain
  4. Biotinylated-JQ1

Biotinylated-JQ1  (Synonyms: Biotin-JQ1)

Cat. No.: HY-145667 Purity: 98.53% ee.: 99.97%
COA Handling Instructions

Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM.

For research use only. We do not sell to patients.

Biotinylated-JQ1 Chemical Structure

Biotinylated-JQ1 Chemical Structure

CAS No. : 1635437-52-3

Size Price Stock Quantity
5 mg USD 540 In-stock
10 mg USD 880 In-stock
25 mg USD 1750 In-stock
50 mg USD 2800 In-stock
100 mg USD 4500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Biotinylated-JQ1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM[1].

In Vitro

Biotinylated-JQ1 (0.1 nM-100 μM; 72 hours) inhibits MM1.S cell proliferation with an EC50 of 0.4 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biotinylated-JQ1 Related Antibodies
Molecular Weight

829.47

Appearance

Solid

Formula

C39H53ClN8O6S2
CAS No.
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4)=O)=O)C6=NN=C(C)N26
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 180 mg/mL (217.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2056 mL 6.0279 mL 12.0559 mL
5 mM 0.2411 mL 1.2056 mL 2.4112 mL
10 mM 0.1206 mL 0.6028 mL 1.2056 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.5 mg/mL (5.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.5 mg/mL (5.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.5 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Biotinylated-JQ1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Biotinylated-JQ11635437-52-3Biotin-JQ1Epigenetic Reader Domainbiotinylated derivativeJQ1bromodomain BRD4MM1.Smultiple myeloma cellsInhibitorinhibitorinhibit

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