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Cat. No.: HY-128597

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BRD-IN-3

BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC₅₀ of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ.

For research use only. We do not sell to patients.

CAS No.: 2351938-32-2
Formula: C₂₁H₂₅N₅O₃
Molecular Weight:395.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BRD-IN-3 Chemical Structure

CAS No.: 2351938-32-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC₅₀ of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ^[1].

IC₅₀ & Target

IC50: PCAF BRD^[1].

All Histone Acetyltransferase Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 2351938-32-2
Molecular Weight 395.45
Formula C₂₁H₂₅N₅O₃
SMILES

CN(C1)C[C@H](NC(N2C)=NC3=C(NC=C3)C2=O)C[C@@H]1C4=CC=C5OCCOC5=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang L, et al. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J Med Chem. 2019 May 9;62(9):4526-4542. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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BRD-IN-3

All Histone Acetyltransferase Isoforms

All Epigenetic Reader Domain Isoforms