4-Phenylcinnamic acid
Based on 1 Customer Validation
4-Phenylcinnamic acid is a weak HDAC2 inhiibitor (IC50 > 5 μM). 4-Phenylcinnamic acid has weak cell growth inhibition against tumor cells.
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- CAS No.: 13026-23-8
- Formule: C15H12O2
- Masse moléculaire:224.26
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HDAC2 >5 μM () |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NB-4 | IC50 |
>10 μM
Compound: 2
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Growth inhibition of human NB4 cells after 72 hrs
Growth inhibition of human NB4 cells after 72 hrs
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[PMID: 26376355] |
| NCI-H460 | IC50 |
>20 μM
Compound: 2
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Growth inhibition of human H460 cells after 72 hrs
Growth inhibition of human H460 cells after 72 hrs
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[PMID: 26376355] |
In Vitro
4-Phenylcinnamic acid (Compound 2) shows an IC50 >5 μM for HDAC2[1].
4-Phenylcinnamic acid (72 h) exhibits weak antiproliferative activity against NB4, HCT116, and H460 human tumor cell lines (IC50 >10 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NB4, HCT116, H460, IGROV-1, IGROV-1/Pt1
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Concentration:0-20 μM
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Incubation Time:72 h
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Result:Showed weak antiproliferative activity against HCT116, H460, and NB4 cells with IC50 >20, >20 and >10 μM.
Showed no antiproliferative activity for IGROV-1 and IGROV-1/Pt1 cells.
Chemical Information
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CAS No. 13026-23-8
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Appearance Solid
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Masse moléculaire 224.26
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Formule C15H12O2
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SMILES
O=C(O)C=CC=1C=CC(=CC1)C=2C=CC=CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
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Fiche technique (269 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Phenylcinnamic acid Related Classifications
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