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Selisistat

(Synonyms: EX-527)
312 Cited Publications
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Based on 312 publication(s) in Google Scholar

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.

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  • Pureté: 99.92%
  • CAS No.: 49843-98-3
  • Formule: C13H13ClN2O
  • Masse moléculaire:248.71
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Selisistat Chemical Structure
    Selisistat Chemical Structure
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
CAS No.: 49843-98-3
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  • Selisistat Chemical Structure
    Selisistat Chemical Structure
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    Selisistat purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2023 Mar.

    Customer Validation
     Selisistat (EX527) treatment significantly increases the levels of C-caspase3 and Bax but decreases the levels of Bcl-2, in 4-OI (4-Octyl Itaconate)-treated chondrocytes.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Metab Brain Dis. 2019 Feb;34(1):203-212. [Abstract]

    Customer Validation
     Western analysis of the protein expression of Sirt1, FoxO1 and LC3 protein in the PC12 with the treatment of MPP+, ECH and EX527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Aug 3:9:854. [Abstract]

    Customer Validation
     Western blotting and quantitative analysis of XBP-1 and ATF6 levels normalized to GAPDH in mice (n=6). Western blotting and quantitative analysis of P-Smad3 and ac-Smad3 levels normalized to T-Smad3 (n=6). I stands for ISO, G stands for GE, and E stands for Ex-527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2018 Mar 6;1863(6):595-603. [Abstract]

    Customer Validation
     LC3 deacetylation levels after erythropoietin (EPO) treatment are detected in PA-treated cells that have been treated with or without the SIRT1 inhibitor EX-527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 May 19;18(5). pii: E1063. [Abstract]

    Customer Validation
     Inhibition of sirt1 and AMPK blocked Rb2-induced hepatic autophagy. HepG2 cells are pretreated with 50 µM Rb2 for 4 h in the presence or absence of the sirt1 inhibitor EX-528 (EX) and the specific AMPK inhibitor Compound C (CC), and then subjected to OA (1 mM for HepG2 and 2 mM for primary mouse hepatocytes) exposure for 12 h. For lipid content determination, intracellular TG are stained by Oil red O (ORO). ORO is then eluted with isopropanol and the optical absorbance of the eluate is measured

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Apr 18;8(32):52783-52791. [Abstract]

    Customer Validation
     Immunoblot analysis of p-AKT (Ser473) and LC3-II in cells treated with 50 nM of TCO for 24 h in the presence and absence of EX-527.

  • Selisistat