Arabinoxylan (Medium viscosity)
Arabinoxylan Medium viscosity is an orally active Dectin-1 splice variant modulator, glucose absorption inhibitor, and chyme viscosity enhancer. Arabinoxylan Medium viscosity inhibits particulate β-glucan-induced Dectin-1A activation and mildly suppresses Dectin-1B activation. In human dendritic cells stimulated with particulate β-glucan, Arabinoxylan Medium viscosity reduces the production of IL-10 and TNF-α, and increases the production of IL-4 and IL-23. Arabinoxylan Medium viscosity also supports antifungal immune responses without activating TLR2, TLR4 or TLR5, and does not induce cytokine production when used to stimulate human dendritic cells alone. Arabinoxylan Medium viscosity increases small intestinal chyme viscosity, gets degraded in the large intestine to produce short-chain fatty acids, reduces glucose absorption and insulin response, and improves glucose homeostasis. Arabinoxylan Medium viscosity supports microbial fermentation and the growth of beneficial microbiota in the gastrointestinal tract, prevents bile acid reabsorption, and delays starch digestion. Arabinoxylan Medium viscosity can be used in research related to type 2 diabetes, impaired glucose tolerance, and metabolic syndrome.
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- Pureté: 95%
- CAS No.: 9040-27-1
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Dectin-1 |
IL-10 |
IL-4 |
IL-23 |
The viscosity of Arabinoxylan solution increases significantly with rising concentration, exhibiting shear-thinning behavior; viscous behavior dominates at low viscosity, while molecular chains undergo hyperentanglement at high viscosity, leading to a transition from viscoelasticity to elasticity. Additionally, the solution follows the Cox-Merz rule and has no complex long-range structure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Arabinoxylan Medium viscosity (accounting for 7.1% of dry matter; administered orally; daily dosing; for 7 consecutive weeks) improves glucose homeostasis, as evidenced by reduced levels of fasting blood glucose, OGTT response, insulin, and HbA1c, while also delaying the onset of diabetes in Zucker diabetic fatty rats[3].
Arabinoxylan Medium viscosity (accounting for 10% of dry matter; p.o.; daily; for 3 consecutive weeks) does not alter glucose homeostasis or incretin hormone levels in normoglycemic pigs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:portal vein-catheterized[3]
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Dosage:7.8% of dry matter
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Administration:p.o.; single dose
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Result:Reduced net portal glucose absorption at 60 minutes postprandially.
Lowered insulin secretion at 30 minutes postprandially.
Reduced incremental area under the curve (iAUC) for glucose to 74% of control value.
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Animal Model:Zucker Diabetic Fatty (ZDF)[3]
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Dosage:7.1% of dry matter
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Administration:p.o.; daily; 7 weeks
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Result:Reduced fasting blood glucose, glucose responses to oral glucose tolerance test (OGTT), insulin concentrations, and glycated hemoglobin A1c (HbA1c) levels compared to control.
Improved insulin sensitivity, increased insulin responses, and delayed the onset of diabetes relative to control.
Chemical Information
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CAS No. 9040-27-1
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Appearance Solid
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Color White to off-white
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SMILES
[Arabinoxylan (Medium viscosity)]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
H2O : 20 mg/mL (Need ultrasonic)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Sahasrabudhe NM, et al. Arabinoxylan activates Dectin-1 and modulates particulate β-glucan-induced Dectin-1 activation. Mol Nutr Food Res. 2016;60(2):458-467. [Content Brief]
[3]. Knudsen KEB, et al. Arabinoxylan Concentrate from Wheat as a Functional Food Ingredient to Improve Glucose Homeostasis. Nutrients. 2025;17(9):1561. Published 2025 Apr 30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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