AZ-11665362
AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.
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- CAS No.: 629645-40-5
- Formule: C22H20N2O2
- Masse moléculaire:344.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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DP2 2.6 nM (IC50) |
CYP2C19 2.5 μM (IC50) |
CYP2C9 5 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
2.6 nM
Compound: 12
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Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells
Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells
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[PMID: 16753296] |
AZ-11665362 (Compound 12) potently binds to human CRTh2 expressed in HEK 293 cells, with an IC50 of 2.6 nM[1].
AZ-11665362 shows selective activity against rat aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9 (IC50 values of 150, 2000, 2500 and 5000 μM), with no measurable activity against COX-1 or COX-2 at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 629645-40-5
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Masse moléculaire 344.41
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Formule C22H20N2O2
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SMILES
O=C(O)CN1C=2C=CC(=CC2C(C=3C=CN=C4C3C=CC=C4C)=C1C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ-11665362 Related Classifications
HY-116811 Related Classifications
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