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Cat. No.: HY-182439

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AZD3778

AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC₅₀ values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.

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CAS No.: 485391-80-8
Formule: C₂₄H₂₉Cl₂N₃O₄S
Masse moléculaire:526.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

AZD3778 Chemical Structure

CAS No.: 485391-80-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

CCR3

8.1 nM (IC₅₀)

Human H₁ Receptor

40 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histamine Receptor :

Voir tous les produits spécifiques à Isoform CCR :

In Vitro

AZD3778 is a CCR3 and histamine H1 receptor inhibitor, with IC₅₀ values of 8.1 nM and 40 nM against human targets, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 485391-80-8
Masse moléculaire 526.48
Formule C₂₄H₂₉Cl₂N₃O₄S
SMILES

O=C(N1CCC(CC1)N2CCC(CC2)OC3=CC=C(C(Cl)=C3)Cl)NS(=O)(C4=CC=C(C)C=C4)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham.

[2]. Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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AZD3778

Voir tous les produits spécifiques à Isoform Histamine Receptor

Voir tous les produits spécifiques à Isoform CCR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AZD3778 Related Classifications

HY-182439 Related Classifications