CDK2-IN-50
CDK2-IN-50 is a CDK2 inhibitor (IC50 = 0.77 nM). CDK2-IN-50 can induce G1 phase arrest, indicating that it has an effective CDK2/cyclin E targeting mechanism. CDK2-IN-50 also has a significant pro-apoptotic effect. CDK2-IN-50 can be used for the study of breast cancer.
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- Formule: C27H27N3O2S
- Masse moléculaire:457.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK2/cyclinE 0.77 nM (IC50) |
CDK2-IN-50 (Compound 8b) (10 μM) exhibits significant growth-inhibiting activity, with an average GI% of 90.51%[1].
CDK2-IN-50 (0.01-100 μM) has a GI50 value as low as 0.33 μM (for breast cancer cell lines), with an average GI50 of 5.58 μM across the entire plate[1].
CDK2-IN-50 (0.33 μM, 24 h) causes cell cycle arrest in the G1 phase, with 77.92% of cells in the G1 phase in MDA-MB-468 cells[1].
CDK2-IN-50 (0.33 μM) induces early apoptosis in MDA-MB-468 cells at a rate of 15.21%, late apoptosis at a rate of 5.87%, and a total apoptosis rate of 21.08%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells
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Concentration:0.33 μM
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Incubation Time:24 h
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Result:Caused cell cycle arrest in the G1 phase, with 77.92% of cells in the G1 phase.
Chemical Information
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Masse moléculaire 457.59
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Formule C27H27N3O2S
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SMILES
O=C(NC1=CC=C(C)C=C1)C2=C(N)C3=C(S2)N=C4CCCCCC4=C3C5=CC=C(OC)C=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2-IN-50 Related Classifications
HY-179231 Related Classifications
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