CEP-9722
Based on 1 publication(s) in Google Scholar
CEP-9722, the proagent of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects.
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- CAS No.: 916574-83-9
- Formule: C24H26N4O3
- Masse moléculaire:418.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) CEP-9722
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Activité biologique
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PARP-1 20 nM (IC50) |
PARP-2 6 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice bearing subcutaneous RT4 human urothelial carcinoma (UC) tumors[1]
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Dosage:100 or 200 mg/kg/day
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Administration:Oral gavage; once daily; for 5 days a week for 4 weeks
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Result:Showed dose-dependent antitumor activity in RT4 xenografts.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 916574-83-9
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Masse moléculaire 418.49
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Formule C24H26N4O3
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SMILES
O=C(N1CN2CCN(C)CC2)C3=C4C5=C(OC)C=CC=C5NC4=C6C(CCC6)=C3C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
[1]. Weiguo Jian, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014 Sep;25(8):878-86. [Content Brief]
[2]. Ruth Plummer, et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Aug;74(2):257-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CEP-9722 Related Classifications
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