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Dactolisib hydrochloride

(Synonyms: BEZ235 hydrochloride; NVP-BEZ235 hydrochloride)
65 Cited Publications
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Based on 65 publication(s) in Google Scholar

Dactolisib (BEZ235) hydrochloride is an orally active, dual pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR with IC50 of 4 nM/5 nM/7 nM/75 nM and 20.7 nM, respectively. Dactolisib hydrochloride (BEZ235) inhibits mTORC1 and mTORC2.

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  • Pureté: 99.41%
  • CAS No.: 2319647-83-9
  • Formule: C30H24ClN5O
  • Masse moléculaire:506.00
  • Stockage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Dactolisib hydrochloride Chemical Structure
    Dactolisib hydrochloride Chemical Structure
  • Experimental Validation Results for Dactolisib hydrochloride
  • Experimental Validation Results for Dactolisib hydrochloride
  • Experimental Validation Results for Dactolisib hydrochloride
  • Experimental Validation Results for Dactolisib hydrochloride
  • Experimental Validation Results for Dactolisib hydrochloride
CAS No.: 2319647-83-9
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  • Dactolisib hydrochloride Chemical Structure
    Dactolisib hydrochloride Chemical Structure
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    Dactolisib hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Aug 9;37(1):188. [Abstract]

    Customer Validation
     Representative images of the western blotting analysis of TSSC3, ATG5, P62, LC3, Src, Akt, mTOR and their phosphorylated versions in MTF and SaOS2 cells. Cells are treated with TSSC3-overexpression, IGF-1, p-YEEI, and BEZ235 separately or in combination.

  • 1/16

    Dactolisib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Res Int. 2018 Aug 5:2018:8372085. [Abstract]

    Customer Validation
     Changes of p-AKT and p-p70 S6K proteins after treatment with NVP-BEZ235 in Ishikawa and Ishikawa-TAX cells. Changes of p-AKT and p-p70 S6K proteins after treatment of Ishikawa and Ishikawa-TAX cells with NVP-BEZ235.

  • 1/16

    Dactolisib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 Jun 8;8:15617. [Abstract]

    Customer Validation
     Immunoblot analysis of KRAS protein levels in parental (P) and resistant derivatives (R1 and R2) following 4 h treatment with the corresponding inhibitors BEZ235 (Dactolisib).

  • 1/16

    Dactolisib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 11;8(28):45470-45483. [Abstract]

    Customer Validation
     Activity of PI3K/AKT/mTOR is monitored by examining phosphorylation of AKT-S473, AKT-T308, and S6 by western blotting.

  • 1/16

    Dactolisib hydrochloride purchased from MedChemExpress. Usage Cited in: Leukemia. 2014 Sep;28(9):1819-27. [Abstract]

    Customer Validation
     Western blot analysis of human T-ALL cell lines treated for 24 hours using DMSO (vehicle control), 1 μM JQ1, 500 nM BEZ235, or both drugs in combination, using the indicated antibodies. Western blot analysis of these T-ALL cell lines following treatment with JQ1, BEZ235 or both drugs in combination reveals cooperative upregulation of BIM protein expression coupled to induction of apoptosis, as assessed by PARP cleavage.

  • Dactolisib hydrochloride