Cat. No.: HY-N4327

Eurycomalactone

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Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

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Pureté: 99.74%
CAS No.: 23062-24-0
Formule: C₁₉H₂₄O₆
Masse moléculaire:348.39

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Eurycomalactone Chemical Structure

CAS No.: 23062-24-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 0.5 μM (NF-κB)^[1]

Voir tous les produits spécifiques à Isoform NF-κB :

Voir tous les produits spécifiques à Isoform Akt :

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.98 μM Compound: 11	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19919052]

In Vitro

Eurycomalactone (24, 48 and 72 h) selectively inhibits the viability of A549 and COR-L23 cells Eurycomalactone inhibits the viability of A549 cells with IC₅₀ values of 20.17, 3.77, and 1.90 μM for 24, 48 and 72 hours, respectively. Eurycomalactone inhibits the viability of COR-L23 cells with IC₅₀ values of 25.02, 2.74, and 1.80 μM for 24, 48 and 72 hours, respectively^[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) promotes Non-small cell lung cancer (NSCLC) cells apoptosis^[2].
Eurycomalactone (0-25.05 μM; 24 h; A549 and COR-L23 cells) induces cell cycle arrest at the radiosensitive G2/M phase and induces apoptosis in irradiated Non-small cell lung cancer (NSCLC) cells. Eurycomalactone downregulated the key G2/M regulatory proteins in irradiated Non-small cell lung cancer (NSCLC) cells^[1].
Eurycomalactone (2.5-25 μM; 24 h; A549 cells) suppressed the repair of radiation-Induced DNA double-strand breaks^[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) suppresses AKT/NF-κB activation in Non-small cell lung cancer (NSCLC) cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

A549 and Calu-1 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

Increased the apoptotic rates in a dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

A549 and COR-L23 cells
Concentration:

1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:

24 hours
Result:

Induced cell cycle arrest at G2/M phase in irradiated cells and increased the sub-G1 population. A549 and COR-L23 cells

Western Blot Analysis^[2]

Cell Line:

A549 and Calu-1 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

Induced the expression levels of active caspase-3 and active PARP (cleaved form), while decreased Bcl-xL and surviving.

Western Blot Analysis^[1]

Cell Line:

A549 and COR-L23 cells
Concentration:

1.57, 2.57, 20.17 and 25.05 μM
Incubation Time:

24 hours
Result:

Downregulated the expression of both G2/M regulatory proteins in a dose-dependent manner.

Western Blot Analysis^[2]

Cell Line:

A549 and COR-L23 cells
Concentration:

2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time:

24 hours
Result:

inhibited the expression levels of p^(S473)-AKT, total AKT, p^(S536)-NF-κB p65 and total NF-κB p65.

Chemical Information

CAS No. 23062-24-0
Appearance Solid
Masse moléculaire 348.39
Formule C₁₉H₂₄O₆
Color White to off-white
SMILES

C[C@]12[C@@]([C@H]([C@@](O3)([H])[C@@](C)([H])[C@]2([H])C3=O)O)([H])[C@]([C@@](C(C)=CC4=O)([H])CC1=O)([C@@H]4O)C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (287.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8703 mL

14.3517 mL

28.7035 mL

5 mM

0.5741 mL

2.8703 mL

5.7407 mL

10 mM

0.2870 mL

1.4352 mL

2.8703 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (288 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. [Content Brief]

[2]. Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. [Content Brief]

[3]. Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8703 mL	14.3517 mL	28.7035 mL	71.7587 mL
	5 mM	0.5741 mL	2.8703 mL	5.7407 mL	14.3517 mL
	10 mM	0.2870 mL	1.4352 mL	2.8703 mL	7.1759 mL
	15 mM	0.1914 mL	0.9568 mL	1.9136 mL	4.7839 mL
	20 mM	0.1435 mL	0.7176 mL	1.4352 mL	3.5879 mL
	25 mM	0.1148 mL	0.5741 mL	1.1481 mL	2.8703 mL
	30 mM	0.0957 mL	0.4784 mL	0.9568 mL	2.3920 mL
	40 mM	0.0718 mL	0.3588 mL	0.7176 mL	1.7940 mL
	50 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	60 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1960 mL
	80 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8970 mL
	100 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7176 mL

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Eurycomalactone

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Voir tous les produits spécifiques à Isoform NF-κB

Voir tous les produits spécifiques à Isoform Akt

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Eurycomalactone Related Classifications

HY-N4327 Related Classifications