Garcinone B
Garcinone B is an NF-κB inhibitor. Garcinone B inhibits LPS-induced NF-κB-dependent transcriptional activation, NF-κB expression, NF-κB-mediated transcription, and IKK, prevents COX-2 transcription, and contributes to immune regulation. Garcinone B inhibits COX enzymes, inhibits prostaglandin E2 release, and contributes to anti-inflammation. Garcinone B blocks ACE2-spike binding, prevents viral entry, inhibits Mpro, and prevents polyprotein cleavage and replication. Garcinone B has antibacterial activity against cariogenic bacteria and bactericidal activity against S. mutans. Garcinone B can be used for research on COVID-19, tuberculosis, and dental caries.
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- CAS No.: 76996-28-6
- Formule: C23H22O6
- Masse moléculaire:394.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
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NF-κB |
IKK |
COX-2 |
prostaglandin E2 |
ACE2 |
Mpro |
In Vitro
Garcinone B inhibits cariogenic bacteria, with an MIC of 0.25 µg/mL against S. mutans, S. sobrinus, and S. mutans ATCC 25175, and an MIC of 0.5 µg/mL against L. acidophilus and L. casei[5].
Garcinone B (1-2 µg/mL; sampled at 0-24 h; plated at 48 h) exerts a bactericidal effect on S. mutans ATCC 25175, achieving bactericidal activity at 1 µg/mL and completely killing the bacteria within 1 h at 2 µg/mL[5].
Garcinone B reduces the cell surface hydrophobicity of S. mutans ATCC 25175 from 90% to 23%[5].
Garcinone B inhibits A23187-induced PGE2 release in C6 rat glioma cells and inhibits LPS-induced NF-κB transcriptional activation[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 76996-28-6
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Masse moléculaire 394.42
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Formule C23H22O6
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SMILES
OC(C(C/C=C(C)/C)=C1O)=CC2=C1C(C3=C4C(OC(C)(C)C=C4)=C(O)C=C3O2)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Garcinone B Related Classifications
HY-149373 Related Classifications
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