JE-133
JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) (HY-D1056)-induced neuroinflammation by regulating JAK/STAT and Nrf2 signaling pathways.
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- CAS No.: 2579171-69-8
- Formule: C23H24O7
- Masse moléculaire:412.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 2579171-69-8
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Masse moléculaire 412.43
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Formule C23H24O7
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SMILES
CCOC([C@@H]1C([C@H]2C3=CC(O)=C(O)C=C3C[C@H](O2)C)=CC4=CC(OC)=CC=C4O1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Tao L, et al. JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways[J]. ACS Chemical Neuroscience, 2024. [Content Brief]
[2]. Tao L, et al. An optically active isochroman-2 H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways[J]. Acta Pharmacologica Sinica, 2021, 42(1): 36-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JE-133 Related Classifications
HY-163151 Related Classifications
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