ML234
ML234 is a dual inhibitor against EZH2/LSD1 with IC50 values of 0.09 and 0.12 μM, respectively. ML234 displays an excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3 and 22RV1. ML234 suppresses the tumor growth in the 22RV1 xenograft mouse model. ML234 is promising for research of anticancer agents in prostate cancer.
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- CAS No.: 3068378-07-1
- Formule: C43H58N4O6
- Masse moléculaire:726.94
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | GI50 |
3.96 μM
Compound: 9j; ML234
|
Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
| LNCaP | GI50 |
1.63 μM
Compound: 9j; ML234
|
Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
| PC-3 | GI50 |
1.04 μM
Compound: 9j; ML234
|
Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
Chemical Information
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CAS No. 3068378-07-1
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Masse moléculaire 726.94
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Formule C43H58N4O6
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SMILES
CC(C(C(NCC1=C(C=C(NC1=O)C)C)=O)=CC(C2=CC=C([C@@H]3C[C@H]3N(C(OC(C)(C)C)=O)CC4CCOCC4)C=C2)=C5)=C5N(CC)C6CCOCC6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)