MPT0B214
MPT0B214 is a microtubule inhibitor that strongly binds to the colchicine binding site of tubulin, preventing tubulin polymerization. MPT0B214 induces apoptosis through a mitochondrial/caspase 9 dependent pathway and shows cytotoxicity across various human tumor cell lines. MPT0B214 can be used for cancer research.
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- CAS No.: 1215208-65-3
- Formule: C20H20N2O5
- Masse moléculaire:368.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.4 nM
Compound: 15
|
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay
|
[PMID: 20148562] |
| KB | IC50 |
0.3 nM
Compound: 15
|
Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay
|
[PMID: 20148562] |
| MKN-45 | IC50 |
0.3 nM
Compound: 15
|
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay
|
[PMID: 20148562] |
| NCI-H460 | IC50 |
0.4 nM
Compound: 15
|
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay
|
[PMID: 20148562] |
Chemical Information
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CAS No. 1215208-65-3
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Masse moléculaire 368.38
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Formule C20H20N2O5
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SMILES
O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=NC3=CC=C(C(N)=C3C=C2)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)