MRS 1477
MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis.
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- CAS No.: 212200-21-0
- Formule: C21H27NO4S
- Masse moléculaire:389.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | IC50 |
10.6 μM
Compound: 7; MRS1477
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Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth by MTT assay
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[PMID: 37000154] |
| MCF7 | IC50 |
3 μM
Compound: 7; MRS1477
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
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[PMID: 37000154] |
| MDA-MB-231 | IC50 |
40.8 μM
Compound: 7; MRS1477
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
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[PMID: 37000154] |
| NIH3T3 | EC50 |
21.3 μM
Compound: 23, MRS-1477
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Agonist-enhancing activity in epsilon-epitope tagged TRPV1 receptor expressed in mouse NIH3T3 cells assessed as capsaicin-induced 45Ca2+ influx by microplate liquid scintillation counter
Agonist-enhancing activity in epsilon-epitope tagged TRPV1 receptor expressed in mouse NIH3T3 cells assessed as capsaicin-induced 45Ca2+ influx by microplate liquid scintillation counter
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[PMID: 18809334] |
MRS1477 evokes Ca2+ signals in MCF7 breast cancer cells, but not in primary breast epithelial cells[1].
MRS1477 (2 μM; 72 h) with capsaicine (10 μM) induces apoptosis and increases reactive oxygen species production and caspase activity[1].
MRS1477 (2 μM) increases capsaicin-evoked TRPV1-mediated current density levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 212200-21-0
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Masse moléculaire 389.51
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Formule C21H27NO4S
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SMILES
CCOC(C1=C(C2=CC=CC=C2)NC(C)=C(C(SCCOC)=O)C1CC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950. [Content Brief]
[2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRS 1477 Related Classifications
HY-110145 Related Classifications
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