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Cat. No.: HY-143882

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MS5033

MS5033 is a potent PROTAC-based AKT (protein kinase B) degrader, with a DC₅₀ of 430 nM in PC3 cells.
(Pink: Akt ligand (HY-48682); Blue: Cereblon ligand (HY-10984); Black: linker (HY-133051)).

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CAS No.: 2376137-29-8
Formule: C₅₁H₆₆ClN₁₁O₁₁
Masse moléculaire:1044.59

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

MS5033 Chemical Structure

CAS No.: 2376137-29-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MS5033 is a potent PROTAC-based AKT (protein kinase B) degrader, with a DC₅₀ of 430 nM in PC3 cells^[1]. (Pink: Akt ligand (HY-48682); Blue: Cereblon ligand (HY-10984); Black: linker (HY-133051)).

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	GI₅₀	4.8 μM Compound: 35; , MS5033	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth by measured after 5 days by IncuCyte zoom live cell analysis Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth by measured after 5 days by IncuCyte zoom live cell analysis	[PMID: 35119851]
PC-3	GI₅₀	10.8 μM Compound: 35; , MS5033	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 5 days by IncuCyte zoom live cell analysis Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 5 days by IncuCyte zoom live cell analysis	[PMID: 35119851]

Chemical Information

CAS No. 2376137-29-8
Masse moléculaire 1044.59
Formule C₅₁H₆₆ClN₁₁O₁₁
SMILES

O=C1C2=C(NCCOCCOCCOCCOCCOCCC(N3CCN(CC3)CC[C@@H](C4=CC=C(C=C4)Cl)NC(C5(CCN(C6=C7C(NC=C7)=NC=N6)CC5)N)=O)=O)C=CC=C2C(N1C8C(NC(CC8)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yu XF, et, al. Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies. J Med Chem. 2022 Feb 24;65(4):3644-3666. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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MS5033

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Akt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

MS5033 Related Classifications

HY-143882 Related Classifications