RIPK2-IN-9
RIPK2-IN-9 is a RIPK2 inhibitor with an IC50 < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis.
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- CAS No.: 3066447-73-9
- Formule: C26H30F2N6O
- Masse moléculaire:480.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
RIPK2-IN-9 exhibits low inhibitory activity against the hERG potassium channel in CHO-hERG cells, with an hERG IC50 of 10 μM, indicating a favorable cardiac safety profile[1].
RIPK2-IN-9 inhibits the protein-protein interaction between RIPK2 and XIAP in HEK293T cells, with an IC50 of 8.1 nM in the NanoBRET assay[1].
RIPK2-IN-9 inhibits NOD2 ligand L18-MDP (HY-148690)-induced TNF-α secretion in human whole blood from healthy donors, with an MSD immunoassay IC50 of 0.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3066447-73-9
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Masse moléculaire 480.55
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Formule C26H30F2N6O
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SMILES
CC1=CC(F)=C(C(NC2CC2)=O)C=C1N3C=C(C4=CN=CC(N[C@@H]5[C@@H](CN(CC5)CC)F)=C4)C=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RIPK2-IN-9 Related Classifications
HY-210247 Related Classifications
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