UMB-136
UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb.
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- CAS No.: 2109805-83-4
- Formule: C24H27N5O2
- Masse moléculaire:417.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
UMB-136 (5 μM; 24 h) significantly induces HIV-1 reactivation[1].
UMB-136 (2.5 μM; 24 h) enhances HIV-1 transcription and viral production by releasing P-TEFb[1].
UMB-136 (2.5 or 5 μM) reverses HIV-1 latency in multiple cell models (THP89GFP, J-Lat full-length (dEnv) clones, primary CD4+ T cell) of HIV-1 latency[1].
UMB-136 (2.5 μM) synergizes with other LRAs (Prostratin HY-107421 or SAHA) to reverse HIV-1 latency in J-Lat cell lines[1].
Combined treatment with UMB-136 (2.5 μM) and PKC activators reverses HIV-1 latency in patient-derived resting CD4+ T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2109805-83-4
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Masse moléculaire 417.50
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Formule C24H27N5O2
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SMILES
COC1=CC(C2=C(ON=C2C)C)=CC=C1C3=C(N4C(C=NC=C4)=N3)NC5CCCCC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UMB-136 Related Classifications
HY-119490 Related Classifications
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