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Cat. No.: HY-N20645

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Capricostatin A

Capricostatin A is a glycosylated heteromeric depsipeptide and Antibacterial agent. Capricostatin A is present in the fungus Austroacremonium gemini MST-FP2131. Capricostatin A inhibits the growth of Gram-positive bacteria, including Bacillus subtilis, Staphylococcus aureus, and MRSA. Capricostatin A exhibits no antifungal activity against Saccharomyces cerevisiae and no cytotoxicity against mammalian cells. Capricostatin A can be used in the research of bacterial infections caused by Bacillus subtilis and Staphylococcus aureus.

For research use only. We do not sell to patients.

Formula: C₃₆H₅₀O₁₂
Molecular Weight:674.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Capricostatin A Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Fungal Metabolite

All Endogenous Metabolite Isoforms :

All Antibiotic Isoforms :

In Vitro

Capricostatin A inhibits the growth of Bacillus subtilis, Staphylococcus aureus, and Methicillin (HY-121544)-resistant S. aureus with MIC values of 1.6 μg mL⁻¹, 3.1 μg mL⁻¹, and 6.3 μg mL⁻¹, respectively, but does not inhibit Saccharomyces cerevisiae, mouse myeloma NS-1 cells, or neonatal foreskin fibroblast cells at the tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 674.78
Formula C₃₆H₅₀O₁₂
SMILES

OC[C@@H](O[C@H]1OC2=CC(CCCCCCC/C=C\CCCCCC)=C(C(OC(C=C3C)=CC(O)=C3C(O)=O)=O)C(O)=C2)[C@@H]([C@@H]([C@H]1O)O)O
Structure Classification
- Antibiotics
Initial Source
- Microorganisms
Austroacremonium gemini
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sbaraini N, et al. The aquastatin biosynthetic gene cluster encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains. Chem Sci. 2024 Oct 24;15(45):18872–80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Capricostatin A

All Endogenous Metabolite Isoforms

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Capricostatin A Related Classifications

HY-N20645 Related Classifications