2. NF-κB Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Immunology/Inflammation
  3. Keap1-Nrf2 Heme Oxygenase (HO) PPAR Interleukin Related SOD
  4. CF-Vanillin

CF-Vanillin is an orally active hypolipidemic/hepatic protector with strong binding affinity for PPAR-α. CF-Vanillin exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway. CF-Vanillin reduces triglyceride and total cholesterol levels and alleviates liver injury. CF-Vanillin can be used in the research of diseases such as hyperlipidemia and liver injury.

For research use only. We do not sell to patients.

CF-Vanillin

CF-Vanillin Chemical Structure

CAS No. : 1323378-95-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CF-Vanillin Related Antibodies

Top Publications Citing Use of Products

View All Heme Oxygenase (HO) Isoform Specific Products:

View All Isoforms
HO-1 HO-2

View All PPAR Isoform Specific Products:

View All Isoforms
PPARα PPARβ/δ PPARγ PPAR PPARδ

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CF-Vanillin is an orally active hypolipidemic/hepatic protector with strong binding affinity for PPAR-α. CF-Vanillin exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway. CF-Vanillin reduces triglyceride and total cholesterol levels and alleviates liver injury. CF-Vanillin can be used in the research of diseases such as hyperlipidemia and liver injury[1].

IC50 & Target[1]

PPARα

 

IL-6

 

HO-1

 

In Vivo

CF-Vanillin (0.1335-0.534 mmol/kg; 7 days) exhibits significant and dose-dependent lipid-lowering activity in hyperlipidemic mice[1].
CF-Vanillin (1.65 mmol/kg; i.g.; 30 days) can alleviate oxidative stress and inflammation by upregulating the Nrf2/HO-1 signaling pathway, thereby significantly reducing liver injury in healthy mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triton WR 1339-induced hyperlipidemic mice[1]
Dosage: 0.534 mmol/kg; 0.267 mmol/kg; 0.1335 mmol/kg
Administration: once daily; 7 days
Result: Reduced serum TG by 28.82% and serum TC by 37.23% at 0.534 mmol/kg.
Reduced serum TG by 24.32% and serum TC by 29.51% at 0.267 mmol/kg.
Reduced serum TG by 21.83% and serum TC by 19.07% at 0.1335 mmol/kg.
Animal Model: Healthy mice[1]
Dosage: 1.65 mmol/kg
Administration: i.g.; once daily; 30 days
Result: Showed no significant difference in body weight relative to control or CF groups.
Significantly reduced liver weight and liver coefficient relative to the CF group.
Significantly reduced serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels relative to the CF group.
Reduced serum alkaline phosphatase (AKP) levels but not significantly.
Significantly increased serum superoxide dismutase (SOD) levels relative to the CF group, significantly increased serum glutathione (GSH) levels relative to the CF group, and significantly reduced serum malondialdehyde (MDA) levels relative to the CF group.
Significantly reduced liver tissue tumor necrosis factor-alpha (TNF-α) protein expression relative to the CF group.
Reduced interleukin-6 (IL-6) protein expression but not significantly.
Showed no inflammatory cell infiltration and only mild hepatocyte swelling, compared to marked hepatocyte swelling, necrosis, nuclear degeneration/dissolution, and inflammatory cell infiltration in the CF group.
Significantly upregulated liver tissue Nrf2 protein expression relative to the CF group, and significantly upregulated HO-1 protein expression relative to the CF group.
Molecular Weight

348.78

Formula

C18H17ClO5
CAS No.
SMILES

ClC1=CC=C(OC(C)(C)C(OC2=C(OC)C=C(C=O)C=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CF-Vanillin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CF-Vanillin1323378-95-5Keap1-Nrf2Heme Oxygenase (HO)PPARInterleukin RelatedSODHeme OxygenasePeroxisome proliferator-activated receptorsILSuperoxide DismutasePPAR-αliver damageoxidative stressinflammationmiceHO-1hyperlipidemic micehyperlipidemiaNrf2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CF-Vanillin
Cat. No.:
HY-181474
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.