Abd110
Based on 1 Customer Validation
Abd110 is a selective ATR PROTAC degrader. Abd110 recruits Cereblon to induce the proteasomal degradation of ATR, and reduces the levels of phosphorylated ATR and downstream phosphorylated CHK1. Abd110 can be used for research on pancreatic cancer and cervical cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.67%
- CAS. Nr.: 3021581-79-0
- Formel: C41H42N8O7S
- Molecular Weight:790.89
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
ATR |
Cereblon |
Chk1 |
In Vitro
Abd110 (Compound 42i) (20 μM; 5 min-24 h) exhibits a plasma protein binding rate of 89.4%, and approximately 75% of its initial concentration remains after incubation in plasma at 37 °C for 24 h[1].
Abd110 (0.1-5 μM; 24 h) induces dose-dependent degradation of ATR and p-ATR in MIA PaCa-2 pancreatic cancer cells. After 24 h of treatment at a concentration of 500 nM, ATR levels decrease to 40% of those in the untreated group[1].
Abd110 (2 μM; 24 h) does not induce cell death in MIA PaCa-2 pancreatic cancer cells after treatment at a concentration of 2 μM for 24 h[1].
Abd110 (50 μM; 24 h) only causes a moderate decrease in the viability of HEK293 embryonic kidney cells at a concentration of 50 μM, and 77.1% of cells remain viable after 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MIA PaCa-2 human pancreatic cancer cells
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Concentration:0.1, 0.5, 1, 2, 5 μM
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Incubation Time:24 h
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Result:Reduced ATR protein levels in a dose-dependent manner.
At 0.1 μM, ATR levels were 60% of untreated control.
At 0.5, 1, and 2 μM, ATR levels were 40% of control.
At 5 μM, ATR levels were 30% of control.
Reduced levels of the active phosphorylated form of ATR (p-ATR T1989).
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Cell Line:MIA PaCa-2 human pancreatic cancer cells
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Concentration:2 μM
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Incubation Time:24 h
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Result:Did not compromise cell vitality, as measured by annexin-V/PI staining.
The extent of cell death was not significantly different from untreated control cells.
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Cell Line:HEK293 human embryonic kidney cells
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Concentration:50 μM
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Incubation Time:24 h followed by 21 h Alamar Blue incubation
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Result:Resulted in 77.1% cell viability relative to medium-only control cells.
Did not produce severe cytotoxic effects at this high concentration.
Chemical Information
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CAS. Nr. 3021581-79-0
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Appearance Solid
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Molecular Weight 790.89
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Formel C41H42N8O7S
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Color Light yellow to yellow
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SMILES
O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (126.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.2644 mL | 6.3220 mL | 12.6440 mL | 31.6100 mL |
| 5 mM | 0.2529 mL | 1.2644 mL | 2.5288 mL | 6.3220 mL | |
| 10 mM | 0.1264 mL | 0.6322 mL | 1.2644 mL | 3.1610 mL | |
| 15 mM | 0.0843 mL | 0.4215 mL | 0.8429 mL | 2.1073 mL | |
| 20 mM | 0.0632 mL | 0.3161 mL | 0.6322 mL | 1.5805 mL | |
| 25 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.2644 mL | |
| 30 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL | |
| 40 mM | 0.0316 mL | 0.1580 mL | 0.3161 mL | 0.7902 mL | |
| 50 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.6322 mL | |
| 60 mM | 0.0211 mL | 0.1054 mL | 0.2107 mL | 0.5268 mL | |
| 80 mM | 0.0158 mL | 0.0790 mL | 0.1580 mL | 0.3951 mL | |
| 100 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3161 mL |
Abd110 Related Classifications
HY-157767 Related Classifications
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Keywords
- Abd110
- 3021581-79-0
- Abd 110
- Abd-110
- ATM/ATR
- PROTACs
- Checkpoint Kinase (Chk)
- cereblon
- proteasomal degradation
- ATR kinase
- HeLa cervix carcinoma cells
- DNA replication stress
- MIA PaCa-2 pancreatic cancer cells
- HEK293 human embryonic kidney cells
- cervix cancer
- phosphorylated CHK1
- pancreatic cancer
- Inhibitor
- inhibitor
- inhibit