Acutissimalignan B
Acutissimalignan B is a natural product. Acutissimalignan B can be isolated from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Acutissimalignan B can reduce the mRNA expression of inflammatory cytokines (iNOS, TNF-α, IL-1β, and IL-6), inhibit the phosphorylation of IκBα, and inhibit the nuclear translocation of NK-κB p65. Acutissimalignan B shows anti-neuroinflammatory effects.
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- CAS. Nr.: 1005390-47-5
- Formel: C20H20O6
- Molecular Weight:356.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
I-kappaBalpha |
p65 |
IL-1β |
IL-6 |
iNOS |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Col2 | ED50 |
5 μg/mL
Compound: 7, acutissimalignan B
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Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
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[PMID: 18271551] |
In Vitro
Acutissimalignan B inhibits LPS-induced NO production in LPS-induced BV-2 microglial cells with an IC50 of 5.41 μM[1].
Acutissimalignan B (1-10 μM; 2 h pretreatment) reduces mRNA expression of NOS, TNF-α, IL-1β, and IL-6 in LPS-induced BV-2 microglial cells[1].
Acutissimalignan B (1-10 μM; 2 h pretreatment) inhibits the NF-κB signaling pathway in LPS-induced BV-2 microglial cells by increasing IκBα levels, decreasing IκBα phosphorylation, and blocking NF-κB p65 nuclear translocation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 18–22 g, LPS-induced via lateral ventricle injection)[1]
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Dosage:10 mg/kg
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Administration:i.g.; 3 days
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Result:Attenuated microglial activation in the cortex and hippocampus (decreased number and cell body area of Iba-1 positive cells); inhibited mRNA expression of iNOS, TNF-α, IL-1β, and IL-6 in the cortex; increased IκBα protein level, decreased IκBα phosphorylation, and inhibited nuclear translocation of NF-κB p65 in the cortex.
Chemical Information
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CAS. Nr. 1005390-47-5
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Molecular Weight 356.37
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Formel C20H20O6
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SMILES
COC(C=C1/C=C(C(OC2)=O)\[C@@H]2CC3=CC(OC)=C(C=C3)O)=C(C=C1)O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Acutissimalignan B Related Classifications
HY-N17562 Related Classifications
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