AMG-8562
AMG-8562 is a TRPV1 modulator. AMG-8562 blocks Capsaicin (HY-10448) activation of TRPV1 without affecting heat activation of TRPV1. AMG-8562 potentiates pH 5 activation of TRPV1. AMG-8562 blocks capsaicin-induced flinching behavior in pain models. AMG-8562 produces significant efficacy in CFA- and skin incision-induced thermal hyperalgesia, and in the Acetic acid (HY-Y0319)-induced writhing models.
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- CAS. Nr.: 1041478-78-7
- Formel: C24H25F3N2O2
- Molecular Weight:430.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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TRPV1 |
Chemical Information
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CAS. Nr. 1041478-78-7
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Molecular Weight 430.47
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Formel C24H25F3N2O2
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SMILES
C(=C/C(NC1=C2C(C[C@@H](O)C2)=CC=C1)=O)\C3=C(C=C(C(F)(F)F)C=C3)N4CCCCC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AMG-8562 Related Classifications
HY-114583 Related Classifications
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