Aspirin-d4
Based on 1 Customer Validation
Aspirin-d4 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.41%
- CAS. Nr.: 97781-16-3
- Formel: C9H4D4O4
- Molecular Weight:184.18
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 97781-16-3
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Unlabeled Cas 50-78-2
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Appearance Solid
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Molecular Weight 184.18
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Formel C9H4D4O4
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Color White to off-white
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SMILES
OC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])OC(C)=O)=O
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Synonyms
Acetylsalicylic acid-d4; ASA-d4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (542.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
[3]. Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8. [Content Brief]
[4]. Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12. [Content Brief]
[5]. Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9. [Content Brief]
[6]. Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4295 mL | 27.1474 mL | 54.2947 mL | 135.7368 mL |
| 5 mM | 1.0859 mL | 5.4295 mL | 10.8589 mL | 27.1474 mL | |
| 10 mM | 0.5429 mL | 2.7147 mL | 5.4295 mL | 13.5737 mL | |
| 15 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL | 9.0491 mL | |
| 20 mM | 0.2715 mL | 1.3574 mL | 2.7147 mL | 6.7868 mL | |
| 25 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 5.4295 mL | |
| 30 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL | 4.5246 mL | |
| 40 mM | 0.1357 mL | 0.6787 mL | 1.3574 mL | 3.3934 mL | |
| 50 mM | 0.1086 mL | 0.5429 mL | 1.0859 mL | 2.7147 mL | |
| 60 mM | 0.0905 mL | 0.4525 mL | 0.9049 mL | 2.2623 mL | |
| 80 mM | 0.0679 mL | 0.3393 mL | 0.6787 mL | 1.6967 mL | |
| 100 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3574 mL |
Aspirin-d4 Related Classifications
HY-14654S1 Related Classifications
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