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Art. -Nr.: HY-182439

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AZD3778

AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC₅₀ values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.

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CAS. Nr.: 485391-80-8
Formel: C₂₄H₂₉Cl₂N₃O₄S
Molecular Weight:526.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZD3778 Chemical Structure

CAS. Nr.: 485391-80-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

CCR3

8.1 nM (IC₅₀)

Human H₁ Receptor

40 nM (IC₅₀)

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

Alle CCR Isoform-spezifische Produkte anzeigen :

In Vitro

AZD3778 is a CCR3 and histamine H1 receptor inhibitor, with IC₅₀ values of 8.1 nM and 40 nM against human targets, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 485391-80-8
Molecular Weight 526.48
Formel C₂₄H₂₉Cl₂N₃O₄S
SMILES

O=C(N1CCC(CC1)N2CCC(CC2)OC3=CC=C(C(Cl)=C3)Cl)NS(=O)(C4=CC=C(C)C=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham.

[2]. Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise

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AZD3778

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Alle CCR Isoform-spezifische Produkte anzeigen