Batanopride
Batanopride (BMY 25801) is a selective 5-HT3 receptor antagonist. Batanopride inhibits chemotherapy-induced emesis, and prevents Cisplatin (HY-17394)-, Cyclophosphamide (HY-17420)-, Doxorubicin (HY-15142A)-, and total body irradiation-induced emesis.
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- CAS. Nr.: 102670-46-2
- Formel: C17H26ClN3O3
- Molecular Weight:355.86
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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5-HT3 Receptor 241 nM (Ki) |
Batanopride binds to 5-HT3 receptors with a Ki of 241.0 nM[1].
Batanopride (10000 nM) does not bind to dopamine D2 receptors at concentrations up to 10000 nM[1].
Batanopride does not bind to serotonergic 5-HT1, 5-HT2, dopamine D1, muscarinic, histamine H1, α-adrenergic, or μ-opioid receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Batanopride (s.c.) prevents Cisplatin (HY-17394)-induced emesis in dogs with an ED50 of 0.05 mg/kg × 2[1].
Batanopride (6-40 mg/kg; s.c.) does not inhibit Apomorphine (HY-12723)-induced stereotypy in the rat and Apomorphine-induced emesis in the dog[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cisplatin-induced emesis in dogs[1]
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Dosage:0.05 mg/kg × 2
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Administration:s.c.; 30 minutes before and 2 hours after Cisplatin administration
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Result:Had an ED50 of 0.05 mg/kg × 2 s.c. for preventing Cisplatin-induced emesis, which was more potent than Metoclopramide (HY-17382) (ED50 = 0.18 mg/kg × 2 s.c.).
Was twice as long-acting as Metoclopramide, with a 50% decline in anti-emetic protection at 5 hours versus 2.5 hours for Metoclopramide at equipotent doses.
Chemical Information
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CAS. Nr. 102670-46-2
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Molecular Weight 355.86
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Formel C17H26ClN3O3
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SMILES
O=C(C1=CC(Cl)=C(C=C1OC(C)C(C)=O)N)NCCN(CC)CC
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Synonyms
BMY 25801
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Batanopride Related Classifications
HY-183136 Related Classifications
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