BRD9757
Based on 1 Customer Validation
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.75%
- CAS. Nr.: 1423058-85-8
- Formel: C6H9NO2
- Molecular Weight:127.14
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
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Covalent Screening Library
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Anti-Blood Cancer Compound Library
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Anti-Liver Cancer Compound Library
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Osteogenesis Compound Library
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Highly Selective Inhibitors Library
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High-Efficiency Gene Editing Compound Library
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Lactylation Compound Library
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Biologische Aktivität
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HDAC6 0.03 μM (IC50) |
HDAC1 0.638 μM (IC50) |
HDAC2 1.79 μM (IC50) |
HDAC3 0.694 μM (IC50) |
HDAC4 21.80 μM (IC50) |
HDAC5 18.32 μM (IC50) |
HDAC7 12.61 μM (IC50) |
HDAC8 1.09 μM (IC50) |
HDAC9 >33.33 μM (IC50) |
BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:10 μM and 30 μM
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Incubation Time:for 24 h
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Result:Increased the level of Ac-tubulin.
Chemical Information
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CAS. Nr. 1423058-85-8
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Appearance Solid
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Molecular Weight 127.14
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Formel C6H9NO2
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Color Light yellow to khaki
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SMILES
O=C(C1=CCCC1)NO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : 12.5 mg/mL (98.32 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.8653 mL | 39.3267 mL | 78.6535 mL | 196.6336 mL |
| 5 mM | 1.5731 mL | 7.8653 mL | 15.7307 mL | 39.3267 mL | |
| 10 mM | 0.7865 mL | 3.9327 mL | 7.8653 mL | 19.6634 mL | |
| 15 mM | 0.5244 mL | 2.6218 mL | 5.2436 mL | 13.1089 mL | |
| 20 mM | 0.3933 mL | 1.9663 mL | 3.9327 mL | 9.8317 mL | |
| 25 mM | 0.3146 mL | 1.5731 mL | 3.1461 mL | 7.8653 mL | |
| 30 mM | 0.2622 mL | 1.3109 mL | 2.6218 mL | 6.5545 mL | |
| 40 mM | 0.1966 mL | 0.9832 mL | 1.9663 mL | 4.9158 mL | |
| 50 mM | 0.1573 mL | 0.7865 mL | 1.5731 mL | 3.9327 mL | |
| 60 mM | 0.1311 mL | 0.6554 mL | 1.3109 mL | 3.2772 mL | |
| 80 mM | 0.0983 mL | 0.4916 mL | 0.9832 mL | 2.4579 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BRD9757 Related Classifications
HY-117554 Related Classifications
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