CXJ-2
CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy.
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- CAS. Nr.: 2919976-92-2
- Formel: C55H87N15O22
- Molecular Weight:1310.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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PI3K |
ERK |
In Vitro
In Vivo
CXJ-2 (0.1 mg/kg, SC, single dose) shows favorable pharmacokinetic properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice (6-8 weeks, 20-24 g, CCl4-induced liver fibrosis model)[1]
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Dosage:150 μg/kg
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Administration:IP, daily, for 3 weeks
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Result:Significantly decreased the HYP (hydroxyproline) content in liver tissue. Decreased collagen deposition. Remarkably diminished hepatic fibrosis.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:0.1 mg/kg
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Administration:SC, single dose (Pharmacokinetic Analysis)
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Result:Showed favorable pharmacokinetic properties (Tmax=0.33 h, T1/2=0.46 h), and displayed enhanced clearance profiles. Displayed significantly higher serum stability with a half-life longer than 36 h.
- BrdU Incorporation Assay
- Cell migration
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- Fibers: Elastic Fiber Staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS. Nr. 2919976-92-2
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Molecular Weight 1310.37
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Formel C55H87N15O22
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Sequence
cyclo(Val-{Iva}-Gly-Ser-Pro-Ser-Ala-Gln-Glu-Glu-Ala-Ser-Pro-Ala)
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Sequence Shortening
cyclo(V-{Iva}-GSPSAQEEASPA)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CXJ-2 Related Classifications
HY-149205 Related Classifications
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