Art. -Nr.: HY-169113

EPZ032597

EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC₅₀ value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma.

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CAS. Nr.: 1887193-58-9
Formel: C₂₀H₂₃N₇O
Molecular Weight:377.44

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Data Sheet (266 KB)

EPZ032597 Chemical Structure

CAS. Nr.: 1887193-58-9

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Biologische Aktivität
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Biologische Aktivität

Beschreibung

EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC₅₀ value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma^[1]^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 5637 cells after 10 days Antiproliferative activity against human 5637 cells after 10 days	[PMID: 29856759]
639-V	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 639-V cells after 10 days Antiproliferative activity against human 639-V cells after 10 days	[PMID: 29856759]
647-V	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 647-V cells after 10 days Antiproliferative activity against human 647-V cells after 10 days	[PMID: 29856759]
769-P	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 769-P cells after 10 days Antiproliferative activity against human 769-P cells after 10 days	[PMID: 29856759]
786-0	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 786-0 cells after 10 days Antiproliferative activity against human 786-0 cells after 10 days	[PMID: 29856759]
A 172	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-172 cells after 10 days Antiproliferative activity against human A-172 cells after 10 days	[PMID: 29856759]
A101D	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A101D cells after 10 days Antiproliferative activity against human A101D cells after 10 days	[PMID: 29856759]
A204	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A204 cells after 10 days Antiproliferative activity against human A204 cells after 10 days	[PMID: 29856759]
A-375	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-375 cells after 10 days Antiproliferative activity against human A-375 cells after 10 days	[PMID: 29856759]
A-427	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-427 cells after 10 days Antiproliferative activity against human A-427 cells after 10 days	[PMID: 29856759]
A-431	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-431 cells after 10 days Antiproliferative activity against human A-431 cells after 10 days	[PMID: 29856759]
A498	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A498 cells after 10 days Antiproliferative activity against human A498 cells after 10 days	[PMID: 29856759]
A549	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A549 cells after 10 days Antiproliferative activity against human A549 cells after 10 days	[PMID: 29856759]
A673	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A673 cells after 10 days Antiproliferative activity against human A673 cells after 10 days	[PMID: 29856759]
ACHN	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ACHN cells after 10 days Antiproliferative activity against human ACHN cells after 10 days	[PMID: 29856759]
AGS	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AGS cells after 10 days Antiproliferative activity against human AGS cells after 10 days	[PMID: 29856759]
AN3-CA	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AN3-CA cells after 10 days Antiproliferative activity against human AN3-CA cells after 10 days	[PMID: 29856759]
ARH-77	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ARH-77 cells after 10 days Antiproliferative activity against human ARH-77 cells after 10 days	[PMID: 29856759]
ASPC1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ASPC1 cells after 10 days Antiproliferative activity against human ASPC1 cells after 10 days	[PMID: 29856759]
AU565	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AU565 cells after 10 days Antiproliferative activity against human AU565 cells after 10 days	[PMID: 29856759]
BeWo	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BeWo cells after 10 days Antiproliferative activity against human BeWo cells after 10 days	[PMID: 29856759]
BFTC-905	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BFTC-905 cells after 10 days Antiproliferative activity against human BFTC-905 cells after 10 days	[PMID: 29856759]
BHT-101	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BHT-101 cells after 10 days Antiproliferative activity against human BHT-101 cells after 10 days	[PMID: 29856759]
BPH-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BPH-1 cells after 10 days Antiproliferative activity against human BPH-1 cells after 10 days	[PMID: 29856759]
BT-20	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-20 cells after 10 days Antiproliferative activity against human BT-20 cells after 10 days	[PMID: 29856759]
BT-474	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-474 cells after 10 days Antiproliferative activity against human BT-474 cells after 10 days	[PMID: 29856759]
BT-549	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-549 cells after 10 days Antiproliferative activity against human BT-549 cells after 10 days	[PMID: 29856759]
BV-173	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BV-173 cells after 10 days Antiproliferative activity against human BV-173 cells after 10 days	[PMID: 29856759]
BXPC-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BXPC-3 cells after 10 days Antiproliferative activity against human BXPC-3 cells after 10 days	[PMID: 29856759]
C32	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C32 cells after 10 days Antiproliferative activity against human C32 cells after 10 days	[PMID: 29856759]
C-33-A	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C-33-A cells after 10 days Antiproliferative activity against human C-33-A cells after 10 days	[PMID: 29856759]
C-4-II	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C-4-II cells after 10 days Antiproliferative activity against human C-4-II cells after 10 days	[PMID: 29856759]
CAKI-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAKI-1 cells after 10 days Antiproliferative activity against human CAKI-1 cells after 10 days	[PMID: 29856759]
CAKI-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAKI-2 cells after 10 days Antiproliferative activity against human CAKI-2 cells after 10 days	[PMID: 29856759]
CAL-27	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAL-27 cells after 10 days Antiproliferative activity against human CAL-27 cells after 10 days	[PMID: 29856759]
CAL-62	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAL-62 cells after 10 days Antiproliferative activity against human CAL-62 cells after 10 days	[PMID: 29856759]
Calu-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Calu-1 cells after 10 days Antiproliferative activity against human Calu-1 cells after 10 days	[PMID: 29856759]
Calu-6	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Calu-6 cells after 10 days Antiproliferative activity against human Calu-6 cells after 10 days	[PMID: 29856759]
CAMA-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAMA-1 cells after 10 days Antiproliferative activity against human CAMA-1 cells after 10 days	[PMID: 29856759]
CAPAN-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAPAN-1 cells after 10 days Antiproliferative activity against human CAPAN-1 cells after 10 days	[PMID: 29856759]
Capan-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Capan2 cells after 10 days Antiproliferative activity against human Capan2 cells after 10 days	[PMID: 29856759]
CCF-STTG1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CCF-STTG1 cells after 10 days Antiproliferative activity against human CCF-STTG1 cells after 10 days	[PMID: 29856759]
CCRF-CEM	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CCRF-CEM cells after 10 days Antiproliferative activity against human CCRF-CEM cells after 10 days	[PMID: 29856759]
CFPAC-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CFPAC-1 cells after 10 days Antiproliferative activity against human CFPAC-1 cells after 10 days	[PMID: 29856759]
CGTH-W-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CGTH-W-1 cells after 10 days Antiproliferative activity against human CGTH-W-1 cells after 10 days	[PMID: 29856759]
ChaGo-K-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ChaGo-K-1 cells after 10 days Antiproliferative activity against human ChaGo-K-1 cells after 10 days	[PMID: 29856759]
CHL-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CHL-1 cells after 10 days Antiproliferative activity against human CHL-1 cells after 10 days	[PMID: 29856759]
CHP-212	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CHP-212 cells after 10 days Antiproliferative activity against human CHP-212 cells after 10 days	[PMID: 29856759]
COLO 201	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO201 cells after 10 days Antiproliferative activity against human COLO201 cells after 10 days	[PMID: 29856759]
COLO 205	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 205 cells after 10 days Antiproliferative activity against human COLO 205 cells after 10 days	[PMID: 29856759]
COLO 320DM	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 320DM cells after 10 days Antiproliferative activity against human COLO 320DM cells after 10 days	[PMID: 29856759]
COLO-320-HSR	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 320HSR cells after 10 days Antiproliferative activity against human COLO 320HSR cells after 10 days	[PMID: 29856759]
COLO-829	IC₅₀	5.73 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO-829 cells after 10 days Antiproliferative activity against human COLO-829 cells after 10 days	[PMID: 29856759]
COR-L105	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COR-L105 cells after 10 days Antiproliferative activity against human COR-L105 cells after 10 days	[PMID: 29856759]
COR-L23	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COR-L23 cells after 10 days Antiproliferative activity against human COR-L23 cells after 10 days	[PMID: 29856759]
CRO-AP2	IC₅₀	0.075 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CRO-AP2 cells after 10 days Antiproliferative activity against human CRO-AP2 cells after 10 days	[PMID: 29856759]
CWR22R	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 22Rv1 cells after 10 days Antiproliferative activity against human 22Rv1 cells after 10 days	[PMID: 29856759]
D283 Med	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human D283 Med cells after 10 days Antiproliferative activity against human D283 Med cells after 10 days	[PMID: 29856759]
Daoy	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Daoy cells after 10 days Antiproliferative activity against human Daoy cells after 10 days	[PMID: 29856759]
Daudi	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Daudi cells after 10 days Antiproliferative activity against human Daudi cells after 10 days	[PMID: 29856759]
DB	IC₅₀	0.663 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DB cells after 10 days Antiproliferative activity against human DB cells after 10 days	[PMID: 29856759]
DBTRG-05MG	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DBTRG-05MG cells after 10 days Antiproliferative activity against human DBTRG-05MG cells after 10 days	[PMID: 29856759]
Detroit 562	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Detroit 562 cells after 10 days Antiproliferative activity against human Detroit 562 cells after 10 days	[PMID: 29856759]
DK-MG	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DK-MG cells after 10 days Antiproliferative activity against human DK-MG cells after 10 days	[PMID: 29856759]
DLD-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DLD-1 cells after 10 days Antiproliferative activity against human DLD-1 cells after 10 days	[PMID: 29856759]
DMS-114	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-114 cells after 10 days Antiproliferative activity against human DMS-114 cells after 10 days	[PMID: 29856759]
DMS-273	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-273 cells after 10 days Antiproliferative activity against human DMS-273 cells after 10 days	[PMID: 29856759]
DMS-53	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-53 cells after 10 days Antiproliferative activity against human DMS-53 cells after 10 days	[PMID: 29856759]
DOHH-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DOHH-2 cells after 10 days Antiproliferative activity against human DOHH-2 cells after 10 days	[PMID: 29856759]
DoTc2-4510	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DoTc2-4510 cells after 10 days Antiproliferative activity against human DoTc2-4510 cells after 10 days	[PMID: 29856759]
DU-145	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DU-145 cells after 10 days Antiproliferative activity against human DU-145 cells after 10 days	[PMID: 29856759]
EB-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EB-3 cells after 10 days Antiproliferative activity against human EB-3 cells after 10 days	[PMID: 29856759]
EFM-19	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EFM-19 cells after 10 days Antiproliferative activity against human EFM-19 cells after 10 days	[PMID: 29856759]
EM-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EM-2 cells after 10 days Antiproliferative activity against human EM-2 cells after 10 days	[PMID: 29856759]
ES-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ES2 cells after 10 days Antiproliferative activity against human ES2 cells after 10 days	[PMID: 29856759]
FaDu	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human FaDu cells after 10 days Antiproliferative activity against human FaDu cells after 10 days	[PMID: 29856759]
G-401	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human G-401 cells after 10 days Antiproliferative activity against human G-401 cells after 10 days	[PMID: 29856759]
G-402	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human G-402 cells after 10 days Antiproliferative activity against human G-402 cells after 10 days	[PMID: 29856759]
H4	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human H4 cells after 10 days Antiproliferative activity against human H4 cells after 10 days	[PMID: 29856759]
HCT-116	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-116 cells after 10 days Antiproliferative activity against human HCT-116 cells after 10 days	[PMID: 29856759]
HCT-15	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-15 cells after 10 days Antiproliferative activity against human HCT-15 cells after 10 days	[PMID: 29856759]
HCT-8	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-8 cells after 10 days Antiproliferative activity against human HCT-8 cells after 10 days	[PMID: 29856759]
HEC-1-A	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HEC-1-A cells after 10 days Antiproliferative activity against human HEC-1-A cells after 10 days	[PMID: 29856759]
HEL 92.1.7	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HEL 92.1.7 cells after 10 days Antiproliferative activity against human HEL 92.1.7 cells after 10 days	[PMID: 29856759]
HeLa	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HeLa cells after 10 days Antiproliferative activity against human HeLa cells after 10 days	[PMID: 29856759]
HepG2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HepG2 cells after 10 days Antiproliferative activity against human HepG2 cells after 10 days	[PMID: 29856759]
HLE	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HLE cells after 10 days Antiproliferative activity against human HLE cells after 10 days	[PMID: 29856759]
HOS	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HOS cells after 10 days Antiproliferative activity against human HOS cells after 10 days	[PMID: 29856759]
HPAF-II	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HPAF-II cells after 10 days Antiproliferative activity against human HPAF-II cells after 10 days	[PMID: 29856759]
Hs 294T	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 294T cells after 10 days Antiproliferative activity against human Hs 294T cells after 10 days	[PMID: 29856759]
Hs 695T	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 695T cells after 10 days Antiproliferative activity against human Hs 695T cells after 10 days	[PMID: 29856759]
Hs 766	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs766T cells after 10 days Antiproliferative activity against human Hs766T cells after 10 days	[PMID: 29856759]
Hs-578T	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 578T cells after 10 days Antiproliferative activity against human Hs 578T cells after 10 days	[PMID: 29856759]
Hs746T	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs746T cells after 10 days Antiproliferative activity against human Hs746T cells after 10 days	[PMID: 29856759]
HT	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT cells after 10 days Antiproliferative activity against human HT cells after 10 days	[PMID: 29856759]
HT-1080	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-1080 cells after 10 days Antiproliferative activity against human HT-1080 cells after 10 days	[PMID: 29856759]
HT1197	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT1197 cells after 10 days Antiproliferative activity against human HT1197 cells after 10 days	[PMID: 29856759]
HT-1376	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-1376 cells after 10 days Antiproliferative activity against human HT-1376 cells after 10 days	[PMID: 29856759]
HT-29	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-29 cells after 10 days Antiproliferative activity against human HT-29 cells after 10 days	[PMID: 29856759]
HT-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-3 cells after 10 days Antiproliferative activity against human HT-3 cells after 10 days	[PMID: 29856759]
HuCCT-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HuCCT-1 cells after 10 days Antiproliferative activity against human HuCCT-1 cells after 10 days	[PMID: 29856759]
HUH-6-clone5	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HUH-6-clone5 cells after 10 days Antiproliferative activity against human HUH-6-clone5 cells after 10 days	[PMID: 29856759]
HuP-T4	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HuP-T4 cells after 10 days Antiproliferative activity against human HuP-T4 cells after 10 days	[PMID: 29856759]
J82	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human J82 cells after 10 days Antiproliferative activity against human J82 cells after 10 days	[PMID: 29856759]
JAR	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human JAR cells after 10 days Antiproliferative activity against human JAR cells after 10 days	[PMID: 29856759]
JEG-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human JEG-3 cells after 10 days Antiproliferative activity against human JEG-3 cells after 10 days	[PMID: 29856759]
J-RT3-T3-5	IC₅₀	0.003 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human J-RT3-T3-5 cells after 10 days Antiproliferative activity against human J-RT3-T3-5 cells after 10 days	[PMID: 29856759]
Jurkat	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Jurkat cells after 10 days Antiproliferative activity against human Jurkat cells after 10 days	[PMID: 29856759]
K562	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human K562 cells after 10 days Antiproliferative activity against human K562 cells after 10 days	[PMID: 29856759]
KLE	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human KLE cells after 10 days Antiproliferative activity against human KLE cells after 10 days	[PMID: 29856759]
KYSE-150 cell line	IC₅₀	>40 nM Compound: 10; EPZ032597	Antiproliferative activity against human KYSE-150 cells assessed as inhibition of cell proliferation Antiproliferative activity against human KYSE-150 cells assessed as inhibition of cell proliferation	[PMID: 35914250]
L-428	IC₅₀	2.61 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human L-428 cells after 10 days Antiproliferative activity against human L-428 cells after 10 days	[PMID: 29856759]
LNCaP	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LNCaP cells after 10 days Antiproliferative activity against human LNCaP cells after 10 days	[PMID: 29856759]
LS-1034	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LS1034 cells after 10 days Antiproliferative activity against human LS1034 cells after 10 days	[PMID: 29856759]
LS174T	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LS174T cells after 10 days Antiproliferative activity against human LS174T cells after 10 days	[PMID: 29856759]
Malme-3M	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Malme-3M cells after 10 days Antiproliferative activity against human Malme-3M cells after 10 days	[PMID: 29856759]
MCF7	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MCF7 cells after 10 days Antiproliferative activity against human MCF7 cells after 10 days	[PMID: 29856759]
MC-IXC	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MC-IXC cells after 10 days Antiproliferative activity against human MC-IXC cells after 10 days	[PMID: 29856759]
MDA-MB-231	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-231 cells after 10 days Antiproliferative activity against human MDA-MB-231 cells after 10 days	[PMID: 29856759]
MDA-MB-436	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-436 cells after 10 days Antiproliferative activity against human MDA-MB-436 cells after 10 days	[PMID: 29856759]
MDA-MB-453	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-453 cells after 10 days Antiproliferative activity against human MDA-MB-453 cells after 10 days	[PMID: 29856759]
MDA-MB-468	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-468 cells after 10 days Antiproliferative activity against human MDA-MB-468 cells after 10 days	[PMID: 29856759]
MEG-01	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MEG-01 cells after 10 days Antiproliferative activity against human MEG-01 cells after 10 days	[PMID: 29856759]
MES-SA	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MES-SA cells after 10 days Antiproliferative activity against human MES-SA cells after 10 days	[PMID: 29856759]
MeWo	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MeWo cells after 10 days Antiproliferative activity against human MeWo cells after 10 days	[PMID: 29856759]
MG-63	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MG-63 cells after 10 days Antiproliferative activity against human MG-63 cells after 10 days	[PMID: 29856759]
MHH-PREB-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MHH-PREB-1 cells after 10 days Antiproliferative activity against human MHH-PREB-1 cells after 10 days	[PMID: 29856759]
MIA PaCa-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Mia PaCa-2 cells after 10 days Antiproliferative activity against human Mia PaCa-2 cells after 10 days	[PMID: 29856759]
MOLT-16	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MOLT-16 cells after 10 days Antiproliferative activity against human MOLT-16 cells after 10 days	[PMID: 29856759]
MOLT-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MOLT-3 cells after 10 days Antiproliferative activity against human MOLT-3 cells after 10 days	[PMID: 29856759]
MV4-11	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MV4-11 cells after 10 days Antiproliferative activity against human MV4-11 cells after 10 days	[PMID: 29856759]
MX1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MX1 cells after 10 days Antiproliferative activity against human MX1 cells after 10 days	[PMID: 29856759]
NALM-6	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NALM-6 cells after 10 days Antiproliferative activity against human NALM-6 cells after 10 days	[PMID: 29856759]
NCI-H292	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H292 cells after 10 days Antiproliferative activity against human NCI-H292 cells after 10 days	[PMID: 29856759]
NCI-H295R	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H295R cells after 10 days Antiproliferative activity against human NCI-H295R cells after 10 days	[PMID: 29856759]
NCI-H441	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H441 cells after 10 days Antiproliferative activity against human NCI-H441 cells after 10 days	[PMID: 29856759]
NCI-H446	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H446 cells after 10 days Antiproliferative activity against human NCI-H446 cells after 10 days	[PMID: 29856759]
NCI-H460	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H460 cells after 10 days Antiproliferative activity against human NCI-H460 cells after 10 days	[PMID: 29856759]
NCI-H508	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H508 cells after 10 days Antiproliferative activity against human NCI-H508 cells after 10 days	[PMID: 29856759]
NCI-H520	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H520 cells after 10 days Antiproliferative activity against human NCI-H520 cells after 10 days	[PMID: 29856759]
NCI-H596	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H596 cells after 10 days Antiproliferative activity against human NCI-H596 cells after 10 days	[PMID: 29856759]
NCI-H661	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H661 cells after 10 days Antiproliferative activity against human NCI-H661 cells after 10 days	[PMID: 29856759]
NCI-H69	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H69 cells after 10 days Antiproliferative activity against human NCI-H69 cells after 10 days	[PMID: 29856759]
NCI-H747	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H747 cells after 10 days Antiproliferative activity against human NCI-H747 cells after 10 days	[PMID: 29856759]
OE19	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OE19 cells after 10 days Antiproliferative activity against human OE19 cells after 10 days	[PMID: 29856759]
OE33	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OE33 cells after 10 days Antiproliferative activity against human OE33 cells after 10 days	[PMID: 29856759]
OVCAR-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OVCAR-3 cells after 10 days Antiproliferative activity against human OVCAR-3 cells after 10 days	[PMID: 29856759]
PANC-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human PANC-1 cells after 10 days Antiproliferative activity against human PANC-1 cells after 10 days	[PMID: 29856759]
PC-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human PC-3 cells after 10 days Antiproliferative activity against human PC-3 cells after 10 days	[PMID: 29856759]
Raji	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Raji cells after 10 days Antiproliferative activity against human Raji cells after 10 days	[PMID: 29856759]
Ramos	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Ramos cells after 10 days Antiproliferative activity against human Ramos cells after 10 days	[PMID: 29856759]
RD	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RD cells after 10 days Antiproliferative activity against human RD cells after 10 days	[PMID: 29856759]
RKO	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RKO cells after 10 days Antiproliferative activity against human RKO cells after 10 days	[PMID: 29856759]
RL95-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RL95-2 cells after 10 days Antiproliferative activity against human RL95-2 cells after 10 days	[PMID: 29856759]
RPMI-6666	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-6666 cells after 10 days Antiproliferative activity against human RPMI-6666 cells after 10 days	[PMID: 29856759]
RPMI-7951	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-7951 cells after 10 days Antiproliferative activity against human RPMI-7951 cells after 10 days	[PMID: 29856759]
RPMI-8226	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-8226 cells after 10 days Antiproliferative activity against human RPMI-8226 cells after 10 days	[PMID: 29856759]
SAOS-2	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SAOS-2 cells after 10 days Antiproliferative activity against human SAOS-2 cells after 10 days	[PMID: 29856759]
SCaBER	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCaBER cells after 10 days Antiproliferative activity against human SCaBER cells after 10 days	[PMID: 29856759]
SCC-25	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-25 cells after 10 days Antiproliferative activity against human SCC-25 cells after 10 days	[PMID: 29856759]
SCC-4	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-4 cells after 10 days Antiproliferative activity against human SCC-4 cells after 10 days	[PMID: 29856759]
SCC-9	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-9 cells after 10 days Antiproliferative activity against human SCC-9 cells after 10 days	[PMID: 29856759]
SH-4	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SH-4 cells after 10 days Antiproliferative activity against human SH-4 cells after 10 days	[PMID: 29856759]
SHP77	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SHP77 cells after 10 days Antiproliferative activity against human SHP77 cells after 10 days	[PMID: 29856759]
SiHa	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SiHa cells after 10 days Antiproliferative activity against human SiHa cells after 10 days	[PMID: 29856759]
SJRH30	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SJRH30 cells after 10 days Antiproliferative activity against human SJRH30 cells after 10 days	[PMID: 29856759]
SJSA-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SJSA-1 cells after 10 days Antiproliferative activity against human SJSA-1 cells after 10 days	[PMID: 29856759]
SK-BR-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-BR-3 cells after 10 days Antiproliferative activity against human SK-BR-3 cells after 10 days	[PMID: 29856759]
SK-LMS-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-LMS-1 cells after 10 days Antiproliferative activity against human SK-LMS-1 cells after 10 days	[PMID: 29856759]
SK-MEL-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL-1 cells after 10 days Antiproliferative activity against human SK-MEL-1 cells after 10 days	[PMID: 29856759]
SK-MEL-28	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL-28 cells after 10 days Antiproliferative activity against human SK-MEL-28 cells after 10 days	[PMID: 29856759]
SK-MEL3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL3 cells after 10 days Antiproliferative activity against human SK-MEL3 cells after 10 days	[PMID: 29856759]
SK-MES-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MES-1 cells after 10 days Antiproliferative activity against human SK-MES-1 cells after 10 days	[PMID: 29856759]
SK-N-AS	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-AS cells after 10 days Antiproliferative activity against human SK-N-AS cells after 10 days	[PMID: 29856759]
SK-N-DZ	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-DZ cells after 10 days Antiproliferative activity against human SK-N-DZ cells after 10 days	[PMID: 29856759]
SK-NEP-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-NEP-1 cells after 10 days Antiproliferative activity against human SK-NEP-1 cells after 10 days	[PMID: 29856759]
SK-N-FI	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-FI cells after 10 days Antiproliferative activity against human SK-N-FI cells after 10 days	[PMID: 29856759]
SK-OV-3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-OV-3 cells after 10 days Antiproliferative activity against human SK-OV-3 cells after 10 days	[PMID: 29856759]
SK-UT-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-UT-1 cells after 10 days Antiproliferative activity against human SK-UT-1 cells after 10 days	[PMID: 29856759]
SNB-19	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNB-19 cells after 10 days Antiproliferative activity against human SNB-19 cells after 10 days	[PMID: 29856759]
SNU1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU1 cells after 10 days Antiproliferative activity against human SNU1 cells after 10 days	[PMID: 29856759]
SNU-16	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-16 cells after 10 days Antiproliferative activity against human SNU-16 cells after 10 days	[PMID: 29856759]
SNU-423	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-423 cells after 10 days Antiproliferative activity against human SNU-423 cells after 10 days	[PMID: 29856759]
SNU-5	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-5 cells after 10 days Antiproliferative activity against human SNU-5 cells after 10 days	[PMID: 29856759]
SR	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SR cells after 10 days Antiproliferative activity against human SR cells after 10 days	[PMID: 29856759]
ST486	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ST486 cells after 10 days Antiproliferative activity against human ST486 cells after 10 days	[PMID: 29856759]
SU.86.86	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SU-86-86 cells after 10 days Antiproliferative activity against human SU-86-86 cells after 10 days	[PMID: 29856759]
SW 954	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW 954 cells after 10 days Antiproliferative activity against human SW 954 cells after 10 days	[PMID: 29856759]
SW 962	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW 962 cells after 10 days Antiproliferative activity against human SW 962 cells after 10 days	[PMID: 29856759]
SW1088	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1088 cells after 10 days Antiproliferative activity against human SW1088 cells after 10 days	[PMID: 29856759]
SW13	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW13 cells after 10 days Antiproliferative activity against human SW13 cells after 10 days	[PMID: 29856759]
SW1353	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1353 cells after 10 days Antiproliferative activity against human SW1353 cells after 10 days	[PMID: 29856759]
SW1417	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1417 cells after 10 days Antiproliferative activity against human SW1417 cells after 10 days	[PMID: 29856759]
SW1463	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1463 cells after 10 days Antiproliferative activity against human SW1463 cells after 10 days	[PMID: 29856759]
SW1783	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1783 cells after 10 days Antiproliferative activity against human SW1783 cells after 10 days	[PMID: 29856759]
SW48	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW48 cells after 10 days Antiproliferative activity against human SW48 cells after 10 days	[PMID: 29856759]
SW480	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW480 cells after 10 days Antiproliferative activity against human SW480 cells after 10 days	[PMID: 29856759]
SW-620	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW620 cells after 10 days Antiproliferative activity against human SW620 cells after 10 days	[PMID: 29856759]
SW684	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW684 cells after 10 days Antiproliferative activity against human SW684 cells after 10 days	[PMID: 29856759]
SW837	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW837 cells after 10 days Antiproliferative activity against human SW837 cells after 10 days	[PMID: 29856759]
SW872	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW872 cells after 10 days Antiproliferative activity against human SW872 cells after 10 days	[PMID: 29856759]
SW900	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW900 cells after 10 days Antiproliferative activity against human SW900 cells after 10 days	[PMID: 29856759]
SW948	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW948 cells after 10 days Antiproliferative activity against human SW948 cells after 10 days	[PMID: 29856759]
SW982	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW982 cells after 10 days Antiproliferative activity against human SW982 cells after 10 days	[PMID: 29856759]
T-24	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T24 cells after 10 days Antiproliferative activity against human T24 cells after 10 days	[PMID: 29856759]
T47D	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T47D cells after 10 days Antiproliferative activity against human T47D cells after 10 days	[PMID: 29856759]
T98G	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T98G cells after 10 days Antiproliferative activity against human T98G cells after 10 days	[PMID: 29856759]
TCC-SUP	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human TCC-SUP cells after 10 days Antiproliferative activity against human TCC-SUP cells after 10 days	[PMID: 29856759]
THP-1	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human THP-1 cells after 10 days Antiproliferative activity against human THP-1 cells after 10 days	[PMID: 29856759]
U138-MG	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U138-MG cells after 10 days Antiproliferative activity against human U138-MG cells after 10 days	[PMID: 29856759]
U-266	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U266B1 cells after 10 days Antiproliferative activity against human U266B1 cells after 10 days	[PMID: 29856759]
U2OS	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U2OS cells after 10 days Antiproliferative activity against human U2OS cells after 10 days	[PMID: 29856759]
U-87MG ATCC	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U-87MG cells after 10 days Antiproliferative activity against human U-87MG cells after 10 days	[PMID: 29856759]
UMUC3	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human UM-UC-3 cells after 10 days Antiproliferative activity against human UM-UC-3 cells after 10 days	[PMID: 29856759]
WiDr	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human WiDr cells after 10 days Antiproliferative activity against human WiDr cells after 10 days	[PMID: 29856759]
Y79	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Y79 cells after 10 days Antiproliferative activity against human Y79 cells after 10 days	[PMID: 29856759]
YAPC	IC₅₀	>10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human YAPC cells after 10 days Antiproliferative activity against human YAPC cells after 10 days	[PMID: 29856759]

Chemical Information

CAS. Nr. 1887193-58-9
Molecular Weight 377.44
Formel C₂₀H₂₃N₇O
SMILES

O=C(C1=CN(C2CC2)N=N1)NC3CN(C3)CC4=CN(CC5=CC=CC=C5)N=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Alshammari E, et al. Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer. World J Gastroenterol. 2022 Aug 7;28(29):3753-3766. [Content Brief]

[2]. Thomenius MJ, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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Art. -Nr.:
Menge:
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CAS. Nr.:
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Menge:

EPZ032597

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

EPZ032597 Related Classifications

HY-169113 Related Classifications