HDAC8-IN-12
HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer.
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- CAS. Nr.: 3028095-13-5
- Formel: C16H17N3O5
- Molecular Weight:331.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
IC50: 0.12 nM (HDAC8)[1]
Chemical Information
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CAS. Nr. 3028095-13-5
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Molecular Weight 331.32
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Formel C16H17N3O5
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SMILES
CN(/C1=C\C2=CC=C(C(OC)=C2)/C=C/C(NO)=O)C(CNC1=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC8-IN-12 Related Classifications
HY-161954 Related Classifications
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