Propentofylline-d6
Propentofylline-d6 (HWA 285-d6) is the d6-labeled Propentofylline (HY-107203). Propentofylline (HWA 285) is an orally active, blood-brain barrier-penetrant phosphodiesterase inhibitor, with an IC50 of 20 μM for cGMP-stimulated PDE II. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
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- CAS. Nr.: 1216516-37-8
- Formel: C15H16D6N4O3
- Molecular Weight:312.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[5]|
PDE Ⅱ |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1216516-37-8
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Unlabeled CAS 55242-55-2
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Molecular Weight 312.40
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Formel C15H16D6N4O3
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SMILES
C(CC)N1C2=C(N(C)C(=O)N(C(C(C(CC(C)=O)([2H])[2H])([2H])[2H])([2H])[2H])C2=O)N=C1
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Synonyms
HWA 285-d6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Noble S, et al. Propentofylline. CNS Drugs. 1997 Sep;8(3):257-264.
[2]. Parkinson FE, et al. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen Pharmacol. 1994 Oct;25(6):1053-8. [Content Brief]
[3]. Goto M, et al. Effects of propentofylline on disorder of learning and memory in rodents. Jpn J Pharmacol. 1987 Nov;45(3):373-8. [Content Brief]
[4]. Rother M, et al. Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. Dement Geriatr Cogn Disord. 1998;9 Suppl 1:36-43. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Propentofylline-d6 Related Classifications
HY-107203S Related Classifications
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Keywords
- Propentofylline-d6
- 1216516-37-8
- HWA 285-d6
- Isotope-Labeled Compounds
- Phosphodiesterase (PDE)
- Adenosine Receptor
- P1 receptor
- adenosine transporter
- mouse leukemic L1210/B23.1 cells
- cyclic nucleotide phosphodiesterase
- adenosine receptor
- human blood mononuclear cells
- mouse astroglial cells
- rat peritoneal macrophages
- rat hippocampal neurons
- rat carcinosarcoma Walker 256 cells
- microglial cells
- Inhibitor
- inhibitor
- inhibit