Propentofylline-d6
Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
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- CAS. Nr.: 1216516-37-8
- Formel: C15H16D6N4O3
- Molecular Weight:312.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1216516-37-8
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Unlabeled CAS 55242-55-2
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Molecular Weight 312.40
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Formel C15H16D6N4O3
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SMILES
C(CC)N1C2=C(N(C)C(=O)N(C(C(C(CC(C)=O)([2H])[2H])([2H])[2H])([2H])[2H])C2=O)N=C1
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Synonyms
HWA 285-d6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Noble S, et al. Propentofylline. CNS Drugs. 1997 Sep;8(3):257-264.
[2]. Parkinson FE, et al. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen Pharmacol. 1994 Oct;25(6):1053-8. [Content Brief]
[3]. Goto M, et al. Effects of propentofylline on disorder of learning and memory in rodents. Jpn J Pharmacol. 1987 Nov;45(3):373-8. [Content Brief]
[4]. Rother M, et al. Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. Dement Geriatr Cogn Disord. 1998;9 Suppl 1:36-43. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Propentofylline-d6 Related Classifications
HY-107203S Related Classifications
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- Propentofylline-d6
- 1216516-37-8
- HWA 285-d6
- Isotope-Labeled Compounds
- Phosphodiesterase (PDE)
- Adenosine Receptor
- adenosine transporter
- mouse leukemic L1210/B23.1 cells
- cyclic nucleotide phosphodiesterase
- adenosine receptor
- human blood mononuclear cells
- mouse astroglial cells
- rat peritoneal macrophages
- rat hippocampal neurons
- rat carcinosarcoma Walker 256 cells
- microglial cells
- Inhibitor
- inhibitor
- inhibit