RIPK2-IN-9
RIPK2-IN-9 is a RIPK2 inhibitor with an IC50 < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis.
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- CAS. Nr.: 3066447-73-9
- Formel: C26H30F2N6O
- Molecular Weight:480.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
Beschreibung
In Vitro
RIPK2-IN-9 exhibits low inhibitory activity against the hERG potassium channel in CHO-hERG cells, with an hERG IC50 of 10 μM, indicating a favorable cardiac safety profile[1].
RIPK2-IN-9 inhibits the protein-protein interaction between RIPK2 and XIAP in HEK293T cells, with an IC50 of 8.1 nM in the NanoBRET assay[1].
RIPK2-IN-9 inhibits NOD2 ligand L18-MDP (HY-148690)-induced TNF-α secretion in human whole blood from healthy donors, with an MSD immunoassay IC50 of 0.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3066447-73-9
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Molecular Weight 480.55
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Formel C26H30F2N6O
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SMILES
CC1=CC(F)=C(C(NC2CC2)=O)C=C1N3C=C(C4=CN=CC(N[C@@H]5[C@@H](CN(CC5)CC)F)=C4)C=N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RIPK2-IN-9 Related Classifications
HY-210247 Related Classifications
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