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Selisistat

(Synonyms: EX-527)
298 Cited Publications
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Based on 298 publication(s) in Google Scholar

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.

For research use only. We do not sell to patients.

  • Purity: 99.92%
  • CAS No.: 49843-98-3
  • Formula: C13H13ClN2O
  • Molecular Weight:248.71
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Selisistat Chemical Structure
    Selisistat Chemical Structure
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
  • Experimental Validation Results for Selisistat
CAS No.: 49843-98-3
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  • Selisistat Chemical Structure
    Selisistat Chemical Structure
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  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2023 Mar.

    Customer Validation
     Selisistat (EX527) treatment significantly increases the levels of C-caspase3 and Bax but decreases the levels of Bcl-2, in 4-OI (4-Octyl Itaconate)-treated chondrocytes.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Metab Brain Dis. 2019 Feb;34(1):203-212. [Abstract]

    Customer Validation
     Western analysis of the protein expression of Sirt1, FoxO1 and LC3 protein in the PC12 with the treatment of MPP+, ECH and EX527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Aug 3:9:854. [Abstract]

    Customer Validation
     Western blotting and quantitative analysis of XBP-1 and ATF6 levels normalized to GAPDH in mice (n=6). Western blotting and quantitative analysis of P-Smad3 and ac-Smad3 levels normalized to T-Smad3 (n=6). I stands for ISO, G stands for GE, and E stands for Ex-527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2018 Mar 6;1863(6):595-603. [Abstract]

    Customer Validation
     LC3 deacetylation levels after erythropoietin (EPO) treatment are detected in PA-treated cells that have been treated with or without the SIRT1 inhibitor EX-527.

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 May 19;18(5). pii: E1063. [Abstract]

    Customer Validation
     Inhibition of sirt1 and AMPK blocked Rb2-induced hepatic autophagy. HepG2 cells are pretreated with 50 µM Rb2 for 4 h in the presence or absence of the sirt1 inhibitor EX-528 (EX) and the specific AMPK inhibitor Compound C (CC), and then subjected to OA (1 mM for HepG2 and 2 mM for primary mouse hepatocytes) exposure for 12 h. For lipid content determination, intracellular TG are stained by Oil red O (ORO). ORO is then eluted with isopropanol and the optical absorbance of the eluate is measured

  • 1/16

    Selisistat purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Apr 18;8(32):52783-52791. [Abstract]

    Customer Validation
     Immunoblot analysis of p-AKT (Ser473) and LC3-II in cells treated with 50 nM of TCO for 24 h in the presence and absence of EX-527.

  • Selisistat