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Cat. No.: HY-183653

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AK442

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3062376-05-7
Formule: C₃₅H₄₀ClN₉O₄
Masse moléculaire:686.20

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AK442 Chemical Structure

CAS No.: 3062376-05-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research^[1].

IC₅₀ & Target^[1]

PRMT4

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

In Vitro

AK442 (10 μM; 6.5 h) binds to PRMT4 in MDA-MB-231 cells and increases the thermal stability of PRMT4 by 2 °C compared with the DMSO control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3062376-05-7
Masse moléculaire 686.20
Formule C₃₅H₄₀ClN₉O₄
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(CCNCC4=CC(C5=CC=C(C=C5)Cl)=CC=C4)CCNC(NCC6=CC=CC=C6)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kulkarni AS, et al. Tailoring PRMT Inhibition: Shifting PRMT7 Selectivity to PRMT4 through "T-Shape" Strategy and "Linker-Specific" Preferences. J Med Chem. 2026 May 14;69(9):9977-9990. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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AK442

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AK442 Related Classifications

HY-183653 Related Classifications