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Denikitug

(Synonyms: GS-1811; JTX-1811)
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Denikitug (GS-1811; JTX-1811) is a humanized monoclonal antibody against CCR8 receptor with a KD of 16.8 pM. Denikitug specifically binds to human CCR8, inhibits CCL1-induced downstream CCR8 signaling. Denikitug selectively depletes cells expressing CCR8 via antibody-dependent cellular cytotoxicity (ADCC). Denikitug promotes anti-tumor immunity and can be used for the research of cancer and immunology.

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  • Pureté: 99.00%
  • CAS No.: 2865822-82-6
  • Masse moléculaire:147.2 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Denikitug
  • Experimental Validation Results for Denikitug
  • Denikitug Chemical Structure
    Denikitug Chemical Structure
CAS No.: 2865822-82-6
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Denikitug Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CCR8 (red) with Denikitug (HY-P990914). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Denikitug Chemical Structure
    1/16
  • Denikitug
  • Flow Cytometry analysis of Raji cells labelling CCR8 (red) with Denikitug (HY-P990914). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa