Cat. No.: HY-145514D

dTAGV-1

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

dTAGV-1 is a potent and selective degrader of FKBP12^F36V-tagged proteins PROTAC degrader. dTAGV-1 can induce degradation of FKBP12^F36V-Nluc in vivo.
(Pink: FKBP12 ligand (HY-114420); Blue: VHL ligand (HY-112078); Black: linker (HY-W012001)).

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Pureté: 99.43%
CAS No.: 2451573-86-5
Formule: C₆₈H₉₀N₆O₁₄S
Masse moléculaire:1247.54

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

dTAGV-1 Chemical Structure

CAS No.: 2451573-86-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

dTAGV-1 is a potent and selective degrader of FKBP12^F36V-tagged proteins PROTAC degrader. dTAGV-1 can induce degradation of FKBP12^F36V-Nluc in vivo. (Pink: FKBP12 ligand (HY-114420); Blue: VHL ligand (HY-112078); Black: linker (HY-W012001)).

IC₅₀ & Target

FKBP12

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

dTAGV-1 (0.1 nM-10 μM; 24 h) induces potent degradation of FKBP12^F36V-Nluc with no effects on FKBP12^WT-Nluc in 293FT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

dTAGV-1 (35 mg/kg; i.p; 3 days) TFA induces degradation of FKBP12^F36V-Nluc in mice^[1].
Pharmacokinetic Analysis in Mice (non-salt form)^[1]

Route	Dose (mg/kg)	T_max (hr)	t_1/2 (hr)	C_max (ng/mL)	AUC_last (hr·ng/mL)	AUC_inf (hr·ng/mL)	CL (mL/min/kg)	V_ss (L/kg)
i.v.	2	0.08	3.02	7780	3245	3329	10.1	0.56
i.p.	10	2.00	4.43	2123	18088	18517	9.05	/
i.p.	2	1.67	3.64	595	2245	3136	10.7	/

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old immunocompromised female mice were transplanted with MV4;11 luc-FKBP12^F36V cells^[1]
Dosage:

35 mg/kg
Administration:

Intraperitoneal injection (i.p.); once daily for 3 days
Result:

Significantly reduced the bioluminescent signal 4 h after the first administration. The signal continuously decreased 4 h after each of the three administrations, and degradation was still evident 28 h after the final administration.

Chemical Information

CAS No. 2451573-86-5
Appearance Solid
Masse moléculaire 1247.54
Formule C₆₈H₉₀N₆O₁₄S
Color White to off-white
SMILES

O=C([C@H]1N(CCCC1)C([C@H](C2=CC(OC)=C(C(OC)=C2)OC)CC)=O)O[C@@H](C3=C(C=CC=C3)OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)CCC7=CC(OC)=C(C=C7)OC
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (6)

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Nature

Synthetic lethality of mRNA quality control complexes in cancer. [Abstract]

2025 Feb;638(8052):1095-1103. PMID: 39910291

dTAGV-1 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8052):1095-1103. [Abstract]

dTAGV-1 hydrochloride (500 nM; 0-48 h) depleted FOCAD protein levels within four hours. Following FOCAD degradation, levels of SKIV2L, TTC37 and AVEN protein decreased by 8 h, reaching a maximum by 2 days in MIAPACA2 FOCAD-dTAG cells.
Sci Adv

FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation. [Abstract]

2025 Nov 28;11(48):eadz2345. PMID: 41313762

dTAGV-1 purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Nov 28;11(48):eadz2345. [Abstract]

Western blot analysis of total RNAPII, degraded RPB1 (tagged with GFP), and RNAPIImut (tagged with HA; WT, Y1F, S2A, T4V, S5A and S7A) levels before and after Doxycycline (Dox) or dTAGV-1 TFA (100 nM) treatment. α-Tubulin served as the loading control.
bioRxiv

2026 Apr 23.
Mayo Clinic

2025.

dTAGV-1 purchased from MedChemExpress. Usage Cited in: Mayo Clinic. 2025.

Representative Western blot analysis of KLF5 after 250 nM dTAGV-1 TFA treatment for 0, 1, 4 and 24 h. HSC70 was used as a loading control.
bioRxiv

2025 July 08.
bioRxiv

2025 March 03.

Solvant et solubilité

In Vitro:

DMSO : 75 mg/mL (60.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8016 mL

4.0079 mL

8.0158 mL

5 mM

0.1603 mL

0.8016 mL

1.6032 mL

10 mM

0.0802 mL

0.4008 mL

0.8016 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11(1):4687. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8016 mL	4.0079 mL	8.0158 mL	20.0394 mL
	5 mM	0.1603 mL	0.8016 mL	1.6032 mL	4.0079 mL
	10 mM	0.0802 mL	0.4008 mL	0.8016 mL	2.0039 mL
	15 mM	0.0534 mL	0.2672 mL	0.5344 mL	1.3360 mL
	20 mM	0.0401 mL	0.2004 mL	0.4008 mL	1.0020 mL
	25 mM	0.0321 mL	0.1603 mL	0.3206 mL	0.8016 mL
	30 mM	0.0267 mL	0.1336 mL	0.2672 mL	0.6680 mL
	40 mM	0.0200 mL	0.1002 mL	0.2004 mL	0.5010 mL
	50 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.4008 mL
	60 mM	0.0134 mL	0.0668 mL	0.1336 mL	0.3340 mL

Keywords

dTAGV-1

6 Cited Publications

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dTAGV-1

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

PROTAC Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) dTAGV-1

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Publications (6)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

dTAGV-1

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

PROTAC Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) dTAGV-1

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Publications (6)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

dTAGV-1 Related Classifications

HY-145514D Related Classifications