GSK702
GSK702, a PROTAC, is a the less active cis-(S,S)-enantiomer of GSK983 (P300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) PROTAC). GSK702 induces only a small decrease of PCAF protein levels. GSK702 binds to CRBN and causes a reduction of IL-1β in macrophages. GSK702 can be used for the study of inflammatory mediators.
(Pink: GCN5/PCAF ligand (HY-101027A); Blue: Cereblon ligand (HY-103596); Black: linker).
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- CAS No.: 2260944-69-0
- Formule: C45H51BrN8O7
- Masse moléculaire:895.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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PCAF |
Cereblon |
IL-1β |
Chemical Information
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CAS No. 2260944-69-0
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Masse moléculaire 895.84
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Formule C45H51BrN8O7
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SMILES
O=C(C1=CC=C([C@H]2CN(C[C@H](C2)NC(C=NN3C)=C(Br)C3=O)C)C=C1)N(C)CCCN(C)C4=CC=C(CCCOC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK702 Related Classifications
HY-185009 Related Classifications
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